FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1584210655> ?p ?o ?g. }

• W1584210655 endingPage "876" @default.
• W1584210655 startingPage "867" @default.
• W1584210655 abstract "This study was carried out to determine the effect of protease-activated receptor-2 (PAR2) activation on the pulmonary chemoreflex responses and on the sensitivity of isolated rat vagal pulmonary chemosensitive neurons. In anaesthetized, spontaneously breathing rats, intratracheal instillation of trypsin (0.8 mg ml(-1), 0.1 ml), an endogenous agonist of PAR2, significantly amplified the capsaicin-induced pulmonary chemoreflex responses. The enhanced responses were completely abolished by perineural capsaicin treatment of both cervical vagi, suggesting the involvement of pulmonary C-fibre afferents. In patch-clamp recording experiments, pretreatment with trypsin (0.1 microM, 2 min) potentiated the capsaicin-induced whole-cell inward current in isolated pulmonary sensory neurons. The potentiating effect of trypsin was mimicked by PAR2-activating peptide (PAR2-AP) in a concentration-dependent manner. PAR2-AP pretreatment (100 microM, 2 min) also markedly enhanced the acid-evoked inward currents in these sensory neurons. Furthermore, the sensitizing effect of PAR2 was completely abolished by pretreatment with either U73122 (1 microM, 4 min), a phospholipase C inhibitor, or chelerythrine (10 microM, 4 min), a protein kinase C (PKC) inhibitor. In summary, our results have demonstrated that activation of PAR2 upregulates the pulmonary chemoreflex sensitivity in vivo and the excitability of isolated pulmonary chemosensitive neurons in vitro, and this effect of PAR2 activation was mediated through the PKC-dependent transduction pathway. These results further suggest that the hypersensitivity of these neurons may play a part in the development of airway hyper-responsiveness resulting from PAR2 activation." @default.
• W1584210655 created "2016-06-24" @default.
• W1584210655 creator A5039762450 @default.
• W1584210655 creator A5068265255 @default.
• W1584210655 date "2006-07-21" @default.
• W1584210655 modified "2023-10-18" @default.
• W1584210655 title "Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease‐activated receptor‐2 in rats" @default.
• W1584210655 cites W1492591187 @default.
• W1584210655 cites W1571278720 @default.
• W1584210655 cites W1573321446 @default.
• W1584210655 cites W1599631170 @default.
• W1584210655 cites W1642728877 @default.
• W1584210655 cites W1656256413 @default.
• W1584210655 cites W1882332667 @default.
• W1584210655 cites W1899663046 @default.
• W1584210655 cites W1958081034 @default.
• W1584210655 cites W1963938486 @default.
• W1584210655 cites W1965072920 @default.
• W1584210655 cites W1966691304 @default.
• W1584210655 cites W1966978776 @default.
• W1584210655 cites W1971579586 @default.
• W1584210655 cites W1973556415 @default.
• W1584210655 cites W1974472405 @default.
• W1584210655 cites W1977056120 @default.
• W1584210655 cites W1986880813 @default.
• W1584210655 cites W1994142025 @default.
• W1584210655 cites W1995189884 @default.
• W1584210655 cites W1999201453 @default.
• W1584210655 cites W2003199954 @default.
• W1584210655 cites W2003262365 @default.
• W1584210655 cites W2004868312 @default.
• W1584210655 cites W2015499364 @default.
• W1584210655 cites W2018799018 @default.
• W1584210655 cites W2023028936 @default.
• W1584210655 cites W2027400620 @default.
• W1584210655 cites W2029478951 @default.
• W1584210655 cites W2031843235 @default.
• W1584210655 cites W2037512992 @default.
• W1584210655 cites W2049100687 @default.
• W1584210655 cites W2087408808 @default.
• W1584210655 cites W2096843723 @default.
• W1584210655 cites W2117468483 @default.
• W1584210655 cites W2124470549 @default.
• W1584210655 cites W2125779675 @default.
• W1584210655 cites W2133543836 @default.
• W1584210655 cites W2137884999 @default.
• W1584210655 cites W2140285237 @default.
• W1584210655 cites W2146050924 @default.
• W1584210655 cites W2147639753 @default.
• W1584210655 cites W2149085099 @default.
• W1584210655 cites W2164402028 @default.
• W1584210655 cites W2170147946 @default.
• W1584210655 cites W2186825337 @default.
• W1584210655 cites W2227514672 @default.
• W1584210655 doi "https://doi.org/10.1113/jphysiol.2006.110312" @default.
• W1584210655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1817730" @default.
• W1584210655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16709636" @default.
• W1584210655 hasPublicationYear "2006" @default.
• W1584210655 type Work @default.
• W1584210655 sameAs 1584210655 @default.
• W1584210655 citedByCount "28" @default.
• W1584210655 countsByYear W15842106552012 @default.
• W1584210655 countsByYear W15842106552013 @default.
• W1584210655 countsByYear W15842106552014 @default.
• W1584210655 countsByYear W15842106552015 @default.
• W1584210655 countsByYear W15842106552016 @default.
• W1584210655 countsByYear W15842106552022 @default.
• W1584210655 crossrefType "journal-article" @default.
• W1584210655 hasAuthorship W1584210655A5039762450 @default.
• W1584210655 hasAuthorship W1584210655A5068265255 @default.
• W1584210655 hasBestOaLocation W15842106552 @default.
• W1584210655 hasConcept C126322002 @default.
• W1584210655 hasConcept C134018914 @default.
• W1584210655 hasConcept C170493617 @default.
• W1584210655 hasConcept C185592680 @default.
• W1584210655 hasConcept C195794163 @default.
• W1584210655 hasConcept C2778597717 @default.
• W1584210655 hasConcept C2778938600 @default.
• W1584210655 hasConcept C2780051329 @default.
• W1584210655 hasConcept C55493867 @default.
• W1584210655 hasConcept C62478195 @default.
• W1584210655 hasConcept C71924100 @default.
• W1584210655 hasConcept C86803240 @default.
• W1584210655 hasConcept C98274493 @default.
• W1584210655 hasConceptScore W1584210655C126322002 @default.
• W1584210655 hasConceptScore W1584210655C134018914 @default.
• W1584210655 hasConceptScore W1584210655C170493617 @default.
• W1584210655 hasConceptScore W1584210655C185592680 @default.
• W1584210655 hasConceptScore W1584210655C195794163 @default.
• W1584210655 hasConceptScore W1584210655C2778597717 @default.
• W1584210655 hasConceptScore W1584210655C2778938600 @default.
• W1584210655 hasConceptScore W1584210655C2780051329 @default.
• W1584210655 hasConceptScore W1584210655C55493867 @default.
• W1584210655 hasConceptScore W1584210655C62478195 @default.
• W1584210655 hasConceptScore W1584210655C71924100 @default.
• W1584210655 hasConceptScore W1584210655C86803240 @default.
• W1584210655 hasConceptScore W1584210655C98274493 @default.
• W1584210655 hasIssue "3" @default.

• next