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• W1584413612 abstract "Physical pharmacy and biopharmaceutics is the study of the relationship between the physical chemical and biological properties and the fate of a drug in vivo, in order to design an optimized dosage form. Such studies are critical to drug and drug product design. The selection of new clinical molecules suitable for drug development is heavily dependent on the scientific discipline of physical pharmacy and biopharmaceutics. The term “physical pharmacy” stems from the application of physical chemistry principles to the area of pharmacy in the design of drug molecules and drug products. Pharmacy is an applied science, composed of principles and methods borrowed from basic sciences such as physics, quantum mechanics, thermodynamics, ionization, equilibrium, chemical stability, kinetics, diffusion, permeation, adsorption and complexation. These principles allow pharmaceutical scientists to better predict quantitatively the solubility, stability, compatibility, manufacturability of drugs, and dissolution, absorption, distribution, metabolism, and elimination of drug products. When the physical chemical and biological properties of drug molecules (i.e. preformulation) are understood, it is possible to design dosage forms for designated routes of administration in humans or animals (i.e., formulation). Collectively, the scientific principles applied in the preformulation and formulation processes is termed “physical pharmacy,” and the application of this is termed “pharmaceutics.” Biopharmaceutics is the study of the factors that influence the bioavailability of a drug in humans and animals, and this information is used to optimize a drug's therapeutic window by enhancing its efficacy and/or reducing side effects. Thus, biopharmaceutics involves the effect of a formulation on drug pharmacokinetics. In this chapter, attention will be focused on a subset of physical pharmacy pertaining to biopharmaceutics in areas of solubility, dissolution and gastrointestinal permeability. Pharmacokinetics and pharmacodynamics based on chemical kinetic principles will also be emphasized.Keywords:pharmaceutical sciences;solubility;intestinal permeability;thermodynamics;bioavailability;pharmacokinetics;pharmacodynamics;biopharmaceutics classification system" @default.
• W1584413612 created "2016-06-24" @default.
• W1584413612 creator A5085839455 @default.
• W1584413612 date "2015-04-28" @default.
• W1584413612 modified "2023-09-23" @default.
• W1584413612 title "Physical Pharmacy and Biopharmaceutics" @default.
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• W1584413612 doi "https://doi.org/10.1002/3527600906.mcb.201500004" @default.
• W1584413612 hasPublicationYear "2015" @default.
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