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- W158443437 abstract "223 Background: We explored how social and emotional factors shaped decisions by ACP to enter an EP trial. Methods: Mixed-methods longitudinal cohort study including validated surveys and open-ended interviews. ACP were recruited at an academic medical center with an EP trials program. Patients were eligible if treating oncologists deemed them likely to exhaust standard treatment in 6-12 months but before being offered EP study enrollment. Surveys measured symptoms, quality of life, decisional preferences, emotions, and demographics. 60 minute semi-structured interviews were audio recorded and transcribed. SAS (statistical) and Atlas.ti (thematic coding) were use for analysis. Results: Of 82 patients in the ACP cohort, 16% went on to initiate EP trial entry. No social and emotional factors were associated with EP initiation except ACP who reported both not “feeling down” and feeling “in control of things in your life” (Table) were more likely to initiate. In interviews, many EP initiates expressed hopefulness and a desire to actively respond to their illness. While none believed they could control their illness, some ACP attributed their sense of control over things to their relationship with their oncologist, and others attributed it to informational networks. Conclusions: A feeling of control and absence of depressive symptoms may be associated with ACP initiation of an EP trial. Further exploration of qualitative data documenting the dynamics of EP decision-making is needed. [Table: see text]" @default.
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- W158443437 date "2014-11-01" @default.
- W158443437 modified "2023-09-24" @default.
- W158443437 title "Social and emotional factors and decisions of advanced cancer patients (ACP) to enter an early-phase (EP) clinical trial." @default.
- W158443437 doi "https://doi.org/10.1200/jco.2014.32.31_suppl.223" @default.
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