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- W1584507402 abstract "Abstract— d-[U-14C]Ribose injected subcutaneously into the rat enters the blood, liver and brain. At 30 min after injection 40-70 per cent of the radioactivity in the brain was found in amino acids and only 2-6 per cent in free sugars. In contrast, free sugars (mainly glucose) and carboxylic acids accounted for most of the radioactivity in liver and blood. Evidence for the entry of [U-14C]ribose into the brain was obtained by intracarotid or intravenous injection of [U-14C]ribose after interrupting the blood supply to the liver and kidney. Under these conditions the radioactivity in the brain was found in amino acids, carboxylic acids and ribose; no significant amount of [14C]glucose was detected in brain or heart. It is concluded that ribose is metabolized directly in vivo in the brain. d-[U-14C]Ribose was metabolized also by brain slices in vitro to form 14C-labelled amino acids and carboxylic acids; the rate was equivalent to the utilization of 0.65 μmol of ribose/g/h. The specific radioactivity of glutamine and of γ-aminobutyrate was similar to or higher than that of glutamate in the brain. These results are discussed in the context of metabolic compartments." @default.
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- W1584507402 date "1971-10-01" @default.
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- W1584507402 title "METABOLISM OF d-[U-14C]RIBOSE IN RAT TISSUES" @default.
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- W1584507402 doi "https://doi.org/10.1111/j.1471-4159.1971.tb09603.x" @default.
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