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• W1584685135 abstract "Introduction: Transdermal delivery has potential advantages over other routes of administration. It could reduce first-pass metabolism associated with oral delivery and is less painful than injections. However, the outermost layer of the skin, the stratum corneum (SC), limits passive diffusion to small lipophilic molecules. Therefore, methods are needed to safely permeabilize the SC so that ionic and larger molecules may be delivered transdermally. Areas covered: This review focuses on low-frequency sonophoresis, microneedles, electroporation and iontophoresis, and combinations of these methods to permeabilize the SC. The mechanisms of enhancements and developments in the last 5 years are discussed. Potentially high-impact applications, including protein delivery, vaccination and sensing are presented. Finally, commercial interest and clinical trials are discussed. Expert opinion: Not all permeabilization methods are appropriate for all applications. Focused studies into applications utilizing the advanta..." @default.
• W1584685135 created "2016-06-24" @default.
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• W1584685135 date "2014-03-01" @default.
• W1584685135 modified "2023-09-26" @default.
• W1584685135 title "Skin permeabilization for transdermal drug delivery: recent advances and future prospects" @default.
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• W1584685135 hasPublicationYear "2014" @default.
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