FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1584702916> ?p ?o ?g. }

• W1584702916 endingPage "523" @default.
• W1584702916 startingPage "515" @default.
• W1584702916 abstract "Liver cirrhosis is no longer considered a homogeneous disease, with two different phases now identified: 'compensated' and 'decompensated' cirrhosis, in which complications of cirrhosis characterize the latter. Within each phase, different stages and predictors should be recognized in order to correctly stratify the prognosis and individualize possible therapeutic options. Key Messages: In compensated cirrhosis the presence of clinically significant portal hypertension [CSPH = hepatic venous pressure gradient (HVPG) ≥10 mm Hg] constitutes the most important independent predictor of several relevant clinical endpoints (formation of esophageal varices; first clinical decompensation). An optimal HVPG response to medical therapy of portal hypertension (HVPG reduction <12 mm Hg or ≥20% vs. the pretreatment value, responders) has been consistently linked to a decrease in the risk of variceal bleeding both in primary and secondary prophylaxis, and to a decrease in the risk of presenting other clinical decompensating events. Furthermore, in patients undergoing secondary prophylaxis of variceal bleeding, being an HVPG responder is associated with an improved survival. HVPG also maintains an independent prognostic value in patients with decompensated cirrhosis. Noninvasive alternatives to HVPG for the prediction of CSPH have been investigated; liver stiffness by transient elastography and the combination of liver stiffness, spleen size by ultrasound and platelet count are currently the best methods to noninvasively diagnose CSPH, with an accuracy of about 90%. Additional factors modulate prognosis in cirrhosis. Liver function (albumin, bilirubin, INR) is independently associated with prognosis both in compensated and decompensated cirrhosis, and in the latter phase renal function also plays a central role. Among clinical cofactors, obesity and diabetes are emerging as variables increasing the risk of progression to decompensation and death in cirrhosis.Prognostic stratification in patients with cirrhosis should take into account a complex interplay of several clinical, hemodynamic and biological variables. The present review summarizes the existing evidence regarding prognostic factors in cirrhosis, with particular emphasis on compensated cirrhosis." @default.
• W1584702916 created "2016-06-24" @default.
• W1584702916 creator A5054120621 @default.
• W1584702916 creator A5077891286 @default.
• W1584702916 date "2015-01-01" @default.
• W1584702916 modified "2023-10-17" @default.
• W1584702916 title "Clinical Evaluation and Prognosis" @default.
• W1584702916 cites W1691185271 @default.
• W1584702916 cites W1964051982 @default.
• W1584702916 cites W1974207107 @default.
• W1584702916 cites W1974508062 @default.
• W1584702916 cites W1978304182 @default.
• W1584702916 cites W1978667341 @default.
• W1584702916 cites W1979706178 @default.
• W1584702916 cites W1982878947 @default.
• W1584702916 cites W1992945715 @default.
• W1584702916 cites W2004337218 @default.
• W1584702916 cites W2011346803 @default.
• W1584702916 cites W2020176664 @default.
• W1584702916 cites W2020757210 @default.
• W1584702916 cites W2022760989 @default.
• W1584702916 cites W2025606754 @default.
• W1584702916 cites W2030892928 @default.
• W1584702916 cites W2032864171 @default.
• W1584702916 cites W2033260776 @default.
• W1584702916 cites W2043718707 @default.
• W1584702916 cites W2044349000 @default.
• W1584702916 cites W2047085389 @default.
• W1584702916 cites W2051598303 @default.
• W1584702916 cites W2055417401 @default.
• W1584702916 cites W2059290576 @default.
• W1584702916 cites W2060729546 @default.
• W1584702916 cites W2067691975 @default.
• W1584702916 cites W2072997218 @default.
• W1584702916 cites W2078434332 @default.
• W1584702916 cites W2088029436 @default.
• W1584702916 cites W2089929983 @default.
• W1584702916 cites W2094639617 @default.
• W1584702916 cites W2098675436 @default.
• W1584702916 cites W2101099470 @default.
• W1584702916 cites W2103588891 @default.
• W1584702916 cites W2105259478 @default.
• W1584702916 cites W2112665890 @default.
• W1584702916 cites W2128366104 @default.
• W1584702916 cites W2130601804 @default.
• W1584702916 cites W2149727669 @default.
• W1584702916 cites W2152547543 @default.
• W1584702916 cites W2155883829 @default.
• W1584702916 cites W2157758575 @default.
• W1584702916 cites W2159845343 @default.
• W1584702916 cites W2162884539 @default.
• W1584702916 cites W2165799837 @default.
• W1584702916 cites W2171716651 @default.
• W1584702916 cites W2280520378 @default.
• W1584702916 cites W4210986718 @default.
• W1584702916 doi "https://doi.org/10.1159/000374100" @default.
• W1584702916 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26159268" @default.
• W1584702916 hasPublicationYear "2015" @default.
• W1584702916 type Work @default.
• W1584702916 sameAs 1584702916 @default.
• W1584702916 citedByCount "8" @default.
• W1584702916 countsByYear W15847029162017 @default.
• W1584702916 countsByYear W15847029162018 @default.
• W1584702916 countsByYear W15847029162020 @default.
• W1584702916 countsByYear W15847029162023 @default.
• W1584702916 crossrefType "journal-article" @default.
• W1584702916 hasAuthorship W1584702916A5054120621 @default.
• W1584702916 hasAuthorship W1584702916A5077891286 @default.
• W1584702916 hasConcept C126322002 @default.
• W1584702916 hasConcept C164705383 @default.
• W1584702916 hasConcept C2776988256 @default.
• W1584702916 hasConcept C2777214474 @default.
• W1584702916 hasConcept C2777595160 @default.
• W1584702916 hasConcept C2778012290 @default.
• W1584702916 hasConcept C2778721985 @default.
• W1584702916 hasConcept C2778808290 @default.
• W1584702916 hasConcept C2780496750 @default.
• W1584702916 hasConcept C2780826214 @default.
• W1584702916 hasConcept C2992208098 @default.
• W1584702916 hasConcept C2994217296 @default.
• W1584702916 hasConcept C56900294 @default.
• W1584702916 hasConcept C71924100 @default.
• W1584702916 hasConcept C90924648 @default.
• W1584702916 hasConceptScore W1584702916C126322002 @default.
• W1584702916 hasConceptScore W1584702916C164705383 @default.
• W1584702916 hasConceptScore W1584702916C2776988256 @default.
• W1584702916 hasConceptScore W1584702916C2777214474 @default.
• W1584702916 hasConceptScore W1584702916C2777595160 @default.
• W1584702916 hasConceptScore W1584702916C2778012290 @default.
• W1584702916 hasConceptScore W1584702916C2778721985 @default.
• W1584702916 hasConceptScore W1584702916C2778808290 @default.
• W1584702916 hasConceptScore W1584702916C2780496750 @default.
• W1584702916 hasConceptScore W1584702916C2780826214 @default.
• W1584702916 hasConceptScore W1584702916C2992208098 @default.
• W1584702916 hasConceptScore W1584702916C2994217296 @default.
• W1584702916 hasConceptScore W1584702916C56900294 @default.
• W1584702916 hasConceptScore W1584702916C71924100 @default.
• W1584702916 hasConceptScore W1584702916C90924648 @default.

• next