FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1584750497> ?p ?o ?g. }

• W1584750497 endingPage "897" @default.
• W1584750497 startingPage "885" @default.
• W1584750497 abstract "Increased release of thromboxane A(2) (TXA(2)) has been shown to be involved in inflammatory bowel diseases. In the present study, we have investigated the effect of a stable TXA(2) analogue (STA(2)) on the electrical parameters in isolated human colonic mucosa. In the human mucosa set between Ussing chambers, STA(2) stimulated Cl- secretion in a concentration-dependent manner with an EC(50) of 0.06 microm. The STA(2)-induced Cl- secretion was significantly inhibited by ONO-3708 (10 microm), a specific TXA(2) receptor antagonist. The effect of STA(2) (0.3 microm) was independent of the colonic segment from which the tissue was obtained, from caecum to rectum. Chromanol 293B, an inhibitor of the cAMP-dependent KvLQT1 channel, attenuated the STA(2)-induced Cl- secretion in the human colonic mucosa (IC(50) value 1.18 microm). We found that KvLQT1 mRNA and protein were expressed in all the tested segments of the human colon. The STA(2)-induced Cl- secretion was significantly inhibited by 8-bromo-2'-monobutyryladenosine-3',5'-cyclic monophosphorothioate (50 microm), a membrane-permeant cAMP antagonist. STA(2) (0.3 microm) significantly increased the intracellular cAMP levels and the short-circuit current via TXA(2) receptor in a human colonic cell line. These results suggest that the TXA(2)-induced Cl- secretion in the colon is mediated via the cAMP pathway in addition to the Ca(2+)-calmodulin pathway which was previously reported." @default.
• W1584750497 created "2016-06-24" @default.
• W1584750497 creator A5002511478 @default.
• W1584750497 creator A5015038980 @default.
• W1584750497 creator A5040013839 @default.
• W1584750497 creator A5078111213 @default.
• W1584750497 creator A5079627883 @default.
• W1584750497 creator A5088628357 @default.
• W1584750497 creator A5018233737 @default.
• W1584750497 date "2005-01-20" @default.
• W1584750497 modified "2023-10-10" @default.
• W1584750497 title "Cyclic AMP-dependent Cl⁻secretion induced by thromboxane A₂in isolated human colon" @default.
• W1584750497 cites W1568799066 @default.
• W1584750497 cites W1668163968 @default.
• W1584750497 cites W1859513094 @default.
• W1584750497 cites W1968403941 @default.
• W1584750497 cites W1968490966 @default.
• W1584750497 cites W1969620149 @default.
• W1584750497 cites W1970005475 @default.
• W1584750497 cites W1975453079 @default.
• W1584750497 cites W1984376381 @default.
• W1584750497 cites W1987599764 @default.
• W1584750497 cites W1991609308 @default.
• W1584750497 cites W1991622675 @default.
• W1584750497 cites W2007665735 @default.
• W1584750497 cites W2007911517 @default.
• W1584750497 cites W2016563543 @default.
• W1584750497 cites W2017381058 @default.
• W1584750497 cites W2019734892 @default.
• W1584750497 cites W2030150497 @default.
• W1584750497 cites W2030845841 @default.
• W1584750497 cites W2042818226 @default.
• W1584750497 cites W2044776257 @default.
• W1584750497 cites W2051750611 @default.
• W1584750497 cites W2052817546 @default.
• W1584750497 cites W2061055235 @default.
• W1584750497 cites W2061441650 @default.
• W1584750497 cites W2062436635 @default.
• W1584750497 cites W2064449936 @default.
• W1584750497 cites W2071109731 @default.
• W1584750497 cites W2073759680 @default.
• W1584750497 cites W2080805885 @default.
• W1584750497 cites W2081772515 @default.
• W1584750497 cites W2097974014 @default.
• W1584750497 cites W2105370490 @default.
• W1584750497 cites W2108627319 @default.
• W1584750497 cites W2144603992 @default.
• W1584750497 cites W2162912541 @default.
• W1584750497 cites W2212540286 @default.
• W1584750497 cites W2258579859 @default.
• W1584750497 cites W2312652235 @default.
• W1584750497 cites W2397846938 @default.
• W1584750497 cites W2410970294 @default.
• W1584750497 cites W4240207797 @default.
• W1584750497 doi "https://doi.org/10.1113/jphysiol.2004.077776" @default.
• W1584750497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1665535" @default.
• W1584750497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15611029" @default.
• W1584750497 hasPublicationYear "2005" @default.
• W1584750497 type Work @default.
• W1584750497 sameAs 1584750497 @default.
• W1584750497 citedByCount "10" @default.
• W1584750497 countsByYear W15847504972012 @default.
• W1584750497 countsByYear W15847504972013 @default.
• W1584750497 countsByYear W15847504972021 @default.
• W1584750497 crossrefType "journal-article" @default.
• W1584750497 hasAuthorship W1584750497A5002511478 @default.
• W1584750497 hasAuthorship W1584750497A5015038980 @default.
• W1584750497 hasAuthorship W1584750497A5018233737 @default.
• W1584750497 hasAuthorship W1584750497A5040013839 @default.
• W1584750497 hasAuthorship W1584750497A5078111213 @default.
• W1584750497 hasAuthorship W1584750497A5079627883 @default.
• W1584750497 hasAuthorship W1584750497A5088628357 @default.
• W1584750497 hasBestOaLocation W15847504972 @default.
• W1584750497 hasConcept C126322002 @default.
• W1584750497 hasConcept C134018914 @default.
• W1584750497 hasConcept C170493617 @default.
• W1584750497 hasConcept C185592680 @default.
• W1584750497 hasConcept C2776785769 @default.
• W1584750497 hasConcept C2776885963 @default.
• W1584750497 hasConcept C2778122271 @default.
• W1584750497 hasConcept C2779932011 @default.
• W1584750497 hasConcept C29688787 @default.
• W1584750497 hasConcept C3019368612 @default.
• W1584750497 hasConcept C49039625 @default.
• W1584750497 hasConcept C519063684 @default.
• W1584750497 hasConcept C55493867 @default.
• W1584750497 hasConcept C71924100 @default.
• W1584750497 hasConcept C79879829 @default.
• W1584750497 hasConcept C86803240 @default.
• W1584750497 hasConcept C89560881 @default.
• W1584750497 hasConceptScore W1584750497C126322002 @default.
• W1584750497 hasConceptScore W1584750497C134018914 @default.
• W1584750497 hasConceptScore W1584750497C170493617 @default.
• W1584750497 hasConceptScore W1584750497C185592680 @default.
• W1584750497 hasConceptScore W1584750497C2776785769 @default.
• W1584750497 hasConceptScore W1584750497C2776885963 @default.
• W1584750497 hasConceptScore W1584750497C2778122271 @default.
• W1584750497 hasConceptScore W1584750497C2779932011 @default.

• next