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- W1584758083 abstract "Abstract The Women's Health Initiative (WHI) Dietary Modification Randomized Controlled Trial (DMT) was the largest randomized, controlled clinical trial to test the effects of a low‐fat dietary pattern on decreasing the risk of incident breast cancer, colorectal cancer, and heart disease. In all, 48,835 healthy post‐menopausal women aged 50–79 years were recruited across 40 clinical centers throughout the United States. Among postmenopausal women, a low‐fat dietary pattern did not result in a statistically significant reduction in invasive breast cancer risk, colorectal cancer risk, or heart disease risk over an 8.1 year average follow‐up period; however, some evidence suggests that risk for breast cancer was reduced among women who entered the study consuming dietary fat within the highest quartile and who demonstrated the greatest overall reduction in dietary fat intake in response to the dietary intervention. Furthermore, the nonsignificant trends observed suggest that any reduced risk associated with a low‐fat dietary pattern may only be evident after a longer follow‐up period. Thus, a planned, nonintervention follow‐up is underway to allow for continued longitudinal evaluation and potentially a more definitive comparison." @default.
- W1584758083 created "2016-06-24" @default.
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- W1584758083 date "2008-03-14" @default.
- W1584758083 modified "2023-10-17" @default.
- W1584758083 title "Women's Health Initiative Dietary Trial" @default.
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- W1584758083 doi "https://doi.org/10.1002/9780471462422.eoct423" @default.
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