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- W1585087015 abstract "Chromatin consists of the DNA and all proteins involved in organizing and regulating DNA structure. The building block of chromatin is the nucleosome, which is composed of 146 base pairs of DNA and a core histone octamer. The core histone oactomer is composed of two heterodimers of histone H2A and histone H2B and a tetramer of histone H3 and histone H4 [1]. The overall chromatin structure is very dynamic in response to diverse biological events. Regulation of chromatin structure is achieved by two major mechanisms. The first is post‐ translational modification (PTM) of histones and other chromatin proteins via phosphoryla‐ tion, methylation, acetylation, ubiquitination and sumoylation [2, 3]. The second is through ATP-dependent nucleosome structure alteration. Cooperation between histone PTMs and chromatin remodelers allows chromatin remodeling to regulate diverse biological events including transcription, chromosome segregation, DNA replication, and DNA repair. In this chapter, we summarize how chromatin structure is regulated during DNA damage response (DDR), focusing particularly on three PTMs: phosphorylation, Poly(ADP-ribosyl)ation (PARylation) and sumoylation. We discuss the DDR in a highly compacted chromatic structure, heterochromatin, as well as the interplay between chromatin remodeling, DNA damage and human aging." @default.
- W1585087015 created "2016-06-24" @default.
- W1585087015 creator A5044419431 @default.
- W1585087015 creator A5062386238 @default.
- W1585087015 creator A5065830847 @default.
- W1585087015 date "2013-04-17" @default.
- W1585087015 modified "2023-10-18" @default.
- W1585087015 title "Chromatin Remodeling in DNA Damage Response and Human Aging" @default.
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- W1585087015 doi "https://doi.org/10.5772/55272" @default.
- W1585087015 hasPublicationYear "2013" @default.
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