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• W1585113885 startingPage "482" @default.
• W1585113885 abstract "We investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mGlu5) in these different types of extinction in rats that self-administer cocaine. We observed that daily context extinction (non-reinforced exposures to the cocaine-taking context with retracted levers) was just as effective as daily lever extinction in reducing cocaine-primed reinstatement compared with passive abstinence. Additionally, systemic injections of the mGlu5 negative allosteric modulator MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine) following each extinction session significantly impaired the ability of context extinction to reduce cocaine-primed reinstatement, without affecting reinstatement after lever extinction or passive abstinence." @default.
• W1585113885 created "2016-06-24" @default.
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• W1585113885 date "2014-04-09" @default.
• W1585113885 modified "2023-09-23" @default.
• W1585113885 title "Extinction of a cocaine-taking context that protects against drug-primed reinstatement is dependent on the metabotropic glutamate 5 receptor" @default.
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• W1585113885 doi "https://doi.org/10.1111/adb.12142" @default.
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