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- W1585194680 abstract "Summary Diagnosis of Alzheimer’s disease (AD) with positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) relies on typical alterations of brain glucose metabolism which are, however, not disease specific. Amyloid- β imaging has not entered clinical routine yet. Post mortem histological specimen of brain tissue from AD patients revealed enhanced expression of the chemotactic cytocine receptor 1 (CCR1). Participants, methods: CCR1-antagonist ZK811460 was labeled with fluorine-18 to explore its possible use as specific diagnostic tool in AD. Tracer characterization comprising PET imaging of brain and metabolite analysis was performed in AD patients and controls. Results: Neither qualitative evaluation nor quantitative compartment analysis of PET data did show any enhanced binding of the 18F-labeled CCR1-antagonist in the brain of AD patients or controls. Conclusion: 18F-ZK811460 did not fulfill the expectation as diagnostic tracer in PET imaging of AD." @default.
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- W1585194680 date "2012-01-01" @default.
- W1585194680 modified "2023-09-26" @default.
- W1585194680 title "18F-labelled CCR1-receptor antagonist is not suitable for imaging of Alzheimer's disease" @default.
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- W1585194680 doi "https://doi.org/10.3413/nukmed-0457-12-01" @default.
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