FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1585273660> ?p ?o ?g. }

• W1585273660 endingPage "11192" @default.
• W1585273660 startingPage "11186" @default.
• W1585273660 abstract "It has been shown by us and others that progesterone inhibits the growth of Trichophyton mentagrophytes and that the organism escapes from this inhibition over time. We report here studies which show that escape from growth inhibition is related to the enzymatic transformation of progesterone to polar metabolites. Isolation and identification of the progesterone metabolites confirm the production of 15α-hydroxyprogesterone. In addition, three other metabolites were isolated. Two of these were determined to be 1-dehydroprogesterone and 11α-hydroxyprogesterone. The third metabolite was a 1-dehydro-hydroxyprogesterone, but the location of the hydroxyl group could not be determined unequivocally. Studies using authentic 15α-hydroxyprogesterone, 1-dehydroprogesterone, and 11α-hydroxyprogesterone reveal that these derivatives are significantly less inhibitory to the growth of T. mentagrophytes than progesterone. Pretreatment of organisms with progesterone augments the rate of metabolism and enhances escape. We have described previously a progesterone-binding protein (PBP) in cytoplasmic extracts of T. mentagrophytes and hypothesized that progesterone mediates growth inhibition by binding to the PBP of this organism. The relative binding affinity that progesterone and its metabolites display for PBP correlates with the relative growth inhibitory potency of these compounds. These results suggest that metabolism of progesterone to more polar and less inhibitory compounds, which exhibit lower affinity for PBP, is the mechanism of escape from progesterone-mediated inhibition of growth in this organism." @default.
• W1585273660 created "2016-06-24" @default.
• W1585273660 creator A5014273536 @default.
• W1585273660 creator A5021143803 @default.
• W1585273660 creator A5036496348 @default.
• W1585273660 creator A5036879729 @default.
• W1585273660 creator A5047511897 @default.
• W1585273660 creator A5048202574 @default.
• W1585273660 creator A5062789120 @default.
• W1585273660 creator A5086220691 @default.
• W1585273660 date "1989-07-01" @default.
• W1585273660 modified "2023-10-16" @default.
• W1585273660 title "Steroid Metabolism as a Mechanism of Escape from Progesterone-mediated Growth Inhibition in Trichophyton mentagrophytes" @default.
• W1585273660 cites W1550476643 @default.
• W1585273660 cites W1553669153 @default.
• W1585273660 cites W1570291627 @default.
• W1585273660 cites W1845435558 @default.
• W1585273660 cites W1892837005 @default.
• W1585273660 cites W1930677984 @default.
• W1585273660 cites W1933440059 @default.
• W1585273660 cites W1957347513 @default.
• W1585273660 cites W1984442241 @default.
• W1585273660 cites W2010911115 @default.
• W1585273660 cites W2012121724 @default.
• W1585273660 cites W2023983768 @default.
• W1585273660 cites W2034236110 @default.
• W1585273660 cites W2037409464 @default.
• W1585273660 cites W2045858652 @default.
• W1585273660 cites W2047059085 @default.
• W1585273660 cites W2080304178 @default.
• W1585273660 cites W2087615262 @default.
• W1585273660 cites W2093451206 @default.
• W1585273660 cites W2125071946 @default.
• W1585273660 cites W2275687581 @default.
• W1585273660 cites W2326595774 @default.
• W1585273660 cites W3004523759 @default.
• W1585273660 doi "https://doi.org/10.1016/s0021-9258(18)60447-8" @default.
• W1585273660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2738064" @default.
• W1585273660 hasPublicationYear "1989" @default.
• W1585273660 type Work @default.
• W1585273660 sameAs 1585273660 @default.
• W1585273660 citedByCount "28" @default.
• W1585273660 countsByYear W15852736602014 @default.
• W1585273660 countsByYear W15852736602015 @default.
• W1585273660 countsByYear W15852736602016 @default.
• W1585273660 countsByYear W15852736602018 @default.
• W1585273660 countsByYear W15852736602022 @default.
• W1585273660 countsByYear W15852736602023 @default.
• W1585273660 crossrefType "journal-article" @default.
• W1585273660 hasAuthorship W1585273660A5014273536 @default.
• W1585273660 hasAuthorship W1585273660A5021143803 @default.
• W1585273660 hasAuthorship W1585273660A5036496348 @default.
• W1585273660 hasAuthorship W1585273660A5036879729 @default.
• W1585273660 hasAuthorship W1585273660A5047511897 @default.
• W1585273660 hasAuthorship W1585273660A5048202574 @default.
• W1585273660 hasAuthorship W1585273660A5062789120 @default.
• W1585273660 hasAuthorship W1585273660A5086220691 @default.
• W1585273660 hasBestOaLocation W15852736601 @default.
• W1585273660 hasConcept C111472728 @default.
• W1585273660 hasConcept C138885662 @default.
• W1585273660 hasConcept C185592680 @default.
• W1585273660 hasConcept C2775874440 @default.
• W1585273660 hasConcept C2779548794 @default.
• W1585273660 hasConcept C2780902042 @default.
• W1585273660 hasConcept C2910306831 @default.
• W1585273660 hasConcept C55493867 @default.
• W1585273660 hasConcept C62231903 @default.
• W1585273660 hasConcept C71315377 @default.
• W1585273660 hasConcept C86803240 @default.
• W1585273660 hasConcept C89423630 @default.
• W1585273660 hasConcept C89611455 @default.
• W1585273660 hasConceptScore W1585273660C111472728 @default.
• W1585273660 hasConceptScore W1585273660C138885662 @default.
• W1585273660 hasConceptScore W1585273660C185592680 @default.
• W1585273660 hasConceptScore W1585273660C2775874440 @default.
• W1585273660 hasConceptScore W1585273660C2779548794 @default.
• W1585273660 hasConceptScore W1585273660C2780902042 @default.
• W1585273660 hasConceptScore W1585273660C2910306831 @default.
• W1585273660 hasConceptScore W1585273660C55493867 @default.
• W1585273660 hasConceptScore W1585273660C62231903 @default.
• W1585273660 hasConceptScore W1585273660C71315377 @default.
• W1585273660 hasConceptScore W1585273660C86803240 @default.
• W1585273660 hasConceptScore W1585273660C89423630 @default.
• W1585273660 hasConceptScore W1585273660C89611455 @default.
• W1585273660 hasIssue "19" @default.
• W1585273660 hasLocation W15852736601 @default.
• W1585273660 hasOpenAccess W1585273660 @default.
• W1585273660 hasPrimaryLocation W15852736601 @default.
• W1585273660 hasRelatedWork W1027110525 @default.
• W1585273660 hasRelatedWork W2032907397 @default.
• W1585273660 hasRelatedWork W2076936257 @default.
• W1585273660 hasRelatedWork W2214688535 @default.
• W1585273660 hasRelatedWork W2227054951 @default.
• W1585273660 hasRelatedWork W2400381190 @default.
• W1585273660 hasRelatedWork W2414848350 @default.
• W1585273660 hasRelatedWork W2460873123 @default.
• W1585273660 hasRelatedWork W3016433141 @default.
• W1585273660 hasRelatedWork W2743931251 @default.

• next