FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1585377204> ?p ?o ?g. }

• W1585377204 endingPage "702" @default.
• W1585377204 startingPage "693" @default.
• W1585377204 abstract "Background: SPARC/osteonectin is an evolutionarily conserved matricellular protein that modulates cell–matrix interaction and cell function. In all vertebrates, SPARC is dynamically expressed during embryogenesis. However, the precise function of SPARC and the regulatory elements required for its expression in particular during early embryogenesis are largely unknown. Results: The present study was undertaken to explore the molecular mechanisms that regulate sparc gene expression by in vivo functional characterization of the sparc promoter and identification of possible putative regulatory elements that govern basal promoter activity. We report here transient expression analyses of eGFP expression from transgenic zebrafish containing a Sparc-iTol2-eGFP-BAC and/or 7.25 kb-sparc-Tol2-eGFP constructs. eGFP expression was specifically found in the notochord, otic vesicle, fin fold, intermediate cell mass, and olfactory placode of BAC and Tol2 transposon vectors injected embryos. Deletion analysis revealed that promoter activity resides in the unique 5′-untranslated intronic region. Computer-based analysis revealed a putative CpG island immediately proximal to the translation start site within the intron sequence. Global inhibition of methylation with 5-Aza-2-deoxycytidine promoted sparc expression in association with decreasing CpG methylation. Conclusions: Taken together, these data identify a contributory role for DNA methylation in regulating sparc expression in zebrafish embryogenesis. Developmental Dynamics 244:693–702, 2015. © 2015 Wiley Periodicals, Inc." @default.
• W1585377204 created "2016-06-24" @default.
• W1585377204 creator A5001523441 @default.
• W1585377204 creator A5003733187 @default.
• W1585377204 creator A5012931863 @default.
• W1585377204 creator A5027463746 @default.
• W1585377204 creator A5032464916 @default.
• W1585377204 creator A5039485135 @default.
• W1585377204 creator A5061072285 @default.
• W1585377204 date "2015-03-31" @default.
• W1585377204 modified "2023-10-18" @default.
• W1585377204 title "Matricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region" @default.
• W1585377204 cites W1538312067 @default.
• W1585377204 cites W1974661974 @default.
• W1585377204 cites W1979066350 @default.
• W1585377204 cites W1987239717 @default.
• W1585377204 cites W1996412513 @default.
• W1585377204 cites W1997900199 @default.
• W1585377204 cites W2004167290 @default.
• W1585377204 cites W2007021646 @default.
• W1585377204 cites W2007401847 @default.
• W1585377204 cites W2016946398 @default.
• W1585377204 cites W2026191732 @default.
• W1585377204 cites W2026332805 @default.
• W1585377204 cites W2047078918 @default.
• W1585377204 cites W2051568429 @default.
• W1585377204 cites W2055679227 @default.
• W1585377204 cites W2073958459 @default.
• W1585377204 cites W2077637821 @default.
• W1585377204 cites W2080581186 @default.
• W1585377204 cites W2086492419 @default.
• W1585377204 cites W2097190788 @default.
• W1585377204 cites W2104552725 @default.
• W1585377204 cites W2107277218 @default.
• W1585377204 cites W2107938410 @default.
• W1585377204 cites W2120043831 @default.
• W1585377204 cites W2125349610 @default.
• W1585377204 cites W2139122477 @default.
• W1585377204 cites W2152059298 @default.
• W1585377204 cites W2153550523 @default.
• W1585377204 cites W2154760977 @default.
• W1585377204 cites W2260417393 @default.
• W1585377204 doi "https://doi.org/10.1002/dvdy.24267" @default.
• W1585377204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25728805" @default.
• W1585377204 hasPublicationYear "2015" @default.
• W1585377204 type Work @default.
• W1585377204 sameAs 1585377204 @default.
• W1585377204 citedByCount "6" @default.
• W1585377204 countsByYear W15853772042016 @default.
• W1585377204 countsByYear W15853772042017 @default.
• W1585377204 countsByYear W15853772042018 @default.
• W1585377204 countsByYear W15853772042019 @default.
• W1585377204 countsByYear W15853772042020 @default.
• W1585377204 countsByYear W15853772042021 @default.
• W1585377204 crossrefType "journal-article" @default.
• W1585377204 hasAuthorship W1585377204A5001523441 @default.
• W1585377204 hasAuthorship W1585377204A5003733187 @default.
• W1585377204 hasAuthorship W1585377204A5012931863 @default.
• W1585377204 hasAuthorship W1585377204A5027463746 @default.
• W1585377204 hasAuthorship W1585377204A5032464916 @default.
• W1585377204 hasAuthorship W1585377204A5039485135 @default.
• W1585377204 hasAuthorship W1585377204A5061072285 @default.
• W1585377204 hasBestOaLocation W15853772041 @default.
• W1585377204 hasConcept C101762097 @default.
• W1585377204 hasConcept C104317684 @default.
• W1585377204 hasConcept C131075544 @default.
• W1585377204 hasConcept C150194340 @default.
• W1585377204 hasConcept C153911025 @default.
• W1585377204 hasConcept C160160445 @default.
• W1585377204 hasConcept C165864922 @default.
• W1585377204 hasConcept C181199279 @default.
• W1585377204 hasConcept C189165786 @default.
• W1585377204 hasConcept C190727270 @default.
• W1585377204 hasConcept C2775893135 @default.
• W1585377204 hasConcept C2776878037 @default.
• W1585377204 hasConcept C2781460891 @default.
• W1585377204 hasConcept C54355233 @default.
• W1585377204 hasConcept C55493867 @default.
• W1585377204 hasConcept C86803240 @default.
• W1585377204 hasConcept C95444343 @default.
• W1585377204 hasConceptScore W1585377204C101762097 @default.
• W1585377204 hasConceptScore W1585377204C104317684 @default.
• W1585377204 hasConceptScore W1585377204C131075544 @default.
• W1585377204 hasConceptScore W1585377204C150194340 @default.
• W1585377204 hasConceptScore W1585377204C153911025 @default.
• W1585377204 hasConceptScore W1585377204C160160445 @default.
• W1585377204 hasConceptScore W1585377204C165864922 @default.
• W1585377204 hasConceptScore W1585377204C181199279 @default.
• W1585377204 hasConceptScore W1585377204C189165786 @default.
• W1585377204 hasConceptScore W1585377204C190727270 @default.
• W1585377204 hasConceptScore W1585377204C2775893135 @default.
• W1585377204 hasConceptScore W1585377204C2776878037 @default.
• W1585377204 hasConceptScore W1585377204C2781460891 @default.
• W1585377204 hasConceptScore W1585377204C54355233 @default.
• W1585377204 hasConceptScore W1585377204C55493867 @default.
• W1585377204 hasConceptScore W1585377204C86803240 @default.
• W1585377204 hasConceptScore W1585377204C95444343 @default.
• W1585377204 hasIssue "5" @default.

• next