FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1585461212> ?p ?o ?g. }

• W1585461212 endingPage "1106" @default.
• W1585461212 startingPage "1098" @default.
• W1585461212 abstract "Abstract IL-23, a heterodimeric cytokine composed of the p40 subunit of IL-12 and a novel p19 subunit, has been shown to be a key player in models of autoimmune chronic inflammation. To investigate the role of IL-23 in host resistance during chronic fungal infection, wild-type, IL-12- (IL-12p35−/−), IL-23- (IL-23p19−/−), and IL-12/IL-23- (p40-deficient) deficient mice on a C57BL/6 background were infected with Cryptococcus neoformans. Following infection, p40-deficient mice demonstrated higher mortality than IL-12p35−/− mice. Reconstitution of p40-deficient mice with rIL-23 prolonged their survival to levels similar to IL-12p35−/− mice. IL-23p19−/− mice showed a moderately reduced survival time and delayed fungal clearance in the liver. Although IFN-γ production was similar in wild-type and IL-23p19−/− mice, production of IL-17 was strongly impaired in the latter. IL-23p19−/− mice produced fewer hepatic granulomata relative to organ burden and showed defective recruitment of mononuclear cells to the brain. Moreover, activation of microglia cells and expression of IL-1β, IL-6, and MCP-1 in the brain was impaired. These results show that IL-23 complements the more dominant role of IL-12 in protection against a chronic fungal infection by an enhanced inflammatory cell response and distinct cytokine regulation." @default.
• W1585461212 created "2016-06-24" @default.
• W1585461212 creator A5004324305 @default.
• W1585461212 creator A5005658143 @default.
• W1585461212 creator A5010798008 @default.
• W1585461212 creator A5011197905 @default.
• W1585461212 creator A5018250332 @default.
• W1585461212 creator A5061327923 @default.
• W1585461212 creator A5068754475 @default.
• W1585461212 creator A5072825908 @default.
• W1585461212 creator A5074518240 @default.
• W1585461212 creator A5082665065 @default.
• W1585461212 date "2006-01-15" @default.
• W1585461212 modified "2023-10-06" @default.
• W1585461212 title "IL-23 Enhances the Inflammatory Cell Response in <i>Cryptococcus neoformans</i> Infection and Induces a Cytokine Pattern Distinct from IL-12" @default.
• W1585461212 cites W1509377507 @default.
• W1585461212 cites W1509960657 @default.
• W1585461212 cites W1702969026 @default.
• W1585461212 cites W1718964427 @default.
• W1585461212 cites W1765079284 @default.
• W1585461212 cites W1802820735 @default.
• W1585461212 cites W1847326477 @default.
• W1585461212 cites W1905324622 @default.
• W1585461212 cites W1948394619 @default.
• W1585461212 cites W1964909764 @default.
• W1585461212 cites W1966999437 @default.
• W1585461212 cites W1968918322 @default.
• W1585461212 cites W1993162648 @default.
• W1585461212 cites W2006249161 @default.
• W1585461212 cites W2009219530 @default.
• W1585461212 cites W2017046428 @default.
• W1585461212 cites W2017684091 @default.
• W1585461212 cites W2035027025 @default.
• W1585461212 cites W2038725731 @default.
• W1585461212 cites W2044325609 @default.
• W1585461212 cites W2060527543 @default.
• W1585461212 cites W2063053561 @default.
• W1585461212 cites W2076889715 @default.
• W1585461212 cites W2087905758 @default.
• W1585461212 cites W2090197666 @default.
• W1585461212 cites W2097139602 @default.
• W1585461212 cites W2104439753 @default.
• W1585461212 cites W2116537360 @default.
• W1585461212 cites W2116828514 @default.
• W1585461212 cites W2119182059 @default.
• W1585461212 cites W2126639608 @default.
• W1585461212 cites W2127704524 @default.
• W1585461212 cites W2131563799 @default.
• W1585461212 cites W2133435354 @default.
• W1585461212 cites W2146333550 @default.
• W1585461212 cites W2147329812 @default.
• W1585461212 cites W2157647207 @default.
• W1585461212 cites W2159943906 @default.
• W1585461212 cites W2160883911 @default.
• W1585461212 cites W2161052986 @default.
• W1585461212 cites W2211199383 @default.
• W1585461212 cites W4210875411 @default.
• W1585461212 cites W4313333839 @default.
• W1585461212 doi "https://doi.org/10.4049/jimmunol.176.2.1098" @default.
• W1585461212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16393998" @default.
• W1585461212 hasPublicationYear "2006" @default.
• W1585461212 type Work @default.
• W1585461212 sameAs 1585461212 @default.
• W1585461212 citedByCount "209" @default.
• W1585461212 countsByYear W15854612122012 @default.
• W1585461212 countsByYear W15854612122013 @default.
• W1585461212 countsByYear W15854612122014 @default.
• W1585461212 countsByYear W15854612122015 @default.
• W1585461212 countsByYear W15854612122016 @default.
• W1585461212 countsByYear W15854612122017 @default.
• W1585461212 countsByYear W15854612122018 @default.
• W1585461212 countsByYear W15854612122019 @default.
• W1585461212 countsByYear W15854612122020 @default.
• W1585461212 countsByYear W15854612122021 @default.
• W1585461212 countsByYear W15854612122022 @default.
• W1585461212 countsByYear W15854612122023 @default.
• W1585461212 crossrefType "journal-article" @default.
• W1585461212 hasAuthorship W1585461212A5004324305 @default.
• W1585461212 hasAuthorship W1585461212A5005658143 @default.
• W1585461212 hasAuthorship W1585461212A5010798008 @default.
• W1585461212 hasAuthorship W1585461212A5011197905 @default.
• W1585461212 hasAuthorship W1585461212A5018250332 @default.
• W1585461212 hasAuthorship W1585461212A5061327923 @default.
• W1585461212 hasAuthorship W1585461212A5068754475 @default.
• W1585461212 hasAuthorship W1585461212A5072825908 @default.
• W1585461212 hasAuthorship W1585461212A5074518240 @default.
• W1585461212 hasAuthorship W1585461212A5082665065 @default.
• W1585461212 hasBestOaLocation W15854612121 @default.
• W1585461212 hasConcept C149532602 @default.
• W1585461212 hasConcept C154317977 @default.
• W1585461212 hasConcept C156730664 @default.
• W1585461212 hasConcept C187316574 @default.
• W1585461212 hasConcept C202751555 @default.
• W1585461212 hasConcept C203014093 @default.
• W1585461212 hasConcept C2776090121 @default.
• W1585461212 hasConcept C2776914184 @default.
• W1585461212 hasConcept C2777893358 @default.
• W1585461212 hasConcept C2778690821 @default.

• next