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- W1585487991 abstract "<b><i>Background:</i></b> The role of glucagon-like peptide-1 receptor (GLP-1R) variants on body weight response after dietary intervention has not been evaluated so far. <b><i>Objective:</i></b> Our aim was to evaluate weight loss and adipocytokine levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs6923761. <b><i>Design:</i></b> A sample of 280 obese subjects was randomized to two hypocaloric diets. <b><i>Results:</i></b> 124 patients (44.3%) had the genotype <i>GG </i>(wild-type) and 156 (55.7%) had another genotype (mutant), i.e.<i> GA </i>(n = 132, 47.1%) or <i>AA </i>(n = 24, 8.6%). With the type I diet (low in carbohydrates) in the wild-type and mutant groups, BMI, weight, fat mass, waist circumference, insulin levels, insulin resistance and triglycerides decreased. Anthropometric parameters were higher in non-A-allele carriers than A-allele carriers. With the type II diet (low in fats) in all genotypes, BMI, weight, fat mass, waist circumference, insulin levels, total cholesterol and LDL cholesterol decreased. <b><i>Conclusion:</i></b> Our data showed better anthropometric parameters in obese subjects with the mutant allele (A) of the rs6923761 GLP-1R polymorphism. A lack of association of this polymorphism with weight loss or biochemical parameters after two different hypocaloric diets was observed." @default.
- W1585487991 created "2016-06-24" @default.
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- W1585487991 date "2013-01-01" @default.
- W1585487991 modified "2023-10-03" @default.
- W1585487991 title "Evaluation of Weight Loss and Adipocytokine Levels after Two Hypocaloric Diets with Different Macronutrient Distribution in Obese Subjects with the rs6923761 Gene Variant of Glucagon-Like Peptide 1 Receptor" @default.
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- W1585487991 doi "https://doi.org/10.1159/000356710" @default.
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