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- W158554865 abstract "Recent data suggests nNOS mediates NO-component of reflex cutaneous vasodilation with passive heat stress. Our hypothesis was nNOS but not eNOS inhibition would attenuate reflex cutaneous vasodilation during dynamic exercise. Protocol 1: subjects performed a VO2 peak test on a supine cycle ergometer. Protocol 2: with experimental arm at heart level subjects cycled in supine posture at 60% VO2 peak to raise core temperature (Tc) 0.8–1.0°C (35–45 min). In protocol 2 subjects were equipped with 4 microdialysis fibers on the forearm and each randomly assigned as: 1) lactated Ringer's (control); 2) 5mM NPLA (nNOS inhibition); 3) 10mM L-NIO (eNOS inhibition); and 4) 20mM L-NAME (non-selective NOS inhibition). At the end of protocol 2 all sites were locally heated to 43°C and infused with SNP to elicit maximal dilation. Mean arterial pressure (MAP), skin blood flow via laser-Doppler flowmetry (LDF), and Tc via ingestible telemetric pill were measured; cutaneous vascular conductance (CVC) was calculated as LDF/MAP and normalized to maximum. In protocol 2 there was no significant difference between control (62±5 %CVCmax) and NPLA (61±6 %CVCmax). L-NIO (38±4 %CVCmax) and L-NAME (41±7 %CVCmax) significantly attenuated CVC compared to control and NPLA (p<0.001 all conditions). There was no difference between L-NIO and L-NAME. We conclude eNOS, not nNOS, contribute to reflex cutaneous vasodilation during dynamic exercise." @default.
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- W158554865 date "2012-04-01" @default.
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- W158554865 title "eNOS and nNOS contribution to reflex cutaneous vasodilation during dynamic exercise in humans" @default.
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- W158554865 doi "https://doi.org/10.1096/fasebj.26.1_supplement.1079.11" @default.
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