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- W158557334 endingPage "89" @default.
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- W158557334 abstract "In the past five to ten years, studies that have focused on the endothelium have taken on a very significant role in the expansion of our understanding of vascular pharmacology. Three major areas of interest have been endothelium-dependent production of vasoactive substances (conversion of angiotensin I); the ability of endothelial cells to metabolize arachidonic acid to various eicosanoid (epoxide and endoperoxide) products; and inactivation of vasoactive compounds (bradykinin, adenosine, norepinephrine, and so on). An interaction or relationship among these areas was established when it was shown that the relaxation or modulation of vascular tone by angiotensin II and bradykinin was mediated by the endothelial production and release of prostacyclin (Dusting et al., 1981; Mullane and Moncada, 1980). In 1980, Furchgott and Zawadzki reported the obligatory role of endothelial cells in the in vitro relaxation of vascular smooth muscle by acetylcholine. Subsequently, numerous other vasodilating substances have been found to have complete or partial endothelium dependence, and the term “endothelium-derived relaxing factor” (EDRF) was coined for the putative mediator of relaxation (Furchgott, 1983; see chapter 1 in this volume)." @default.
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- W158557334 date "1988-01-01" @default.
- W158557334 modified "2023-09-25" @default.
- W158557334 title "Metabolism of Arachidonic Acid and Release of Endothelium-Derived Relaxing Factors" @default.
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- W158557334 doi "https://doi.org/10.1007/978-1-4612-4588-9_4" @default.
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