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- W1585617611 abstract "Despite the effects of glucocorticoids on immune function, relatively little is known about glucocorticoid-inducible genes and how their products may regulate lymphocyte function. Using DNA microarray technology to analyze gene expression in PBMC from healthy donors, we identified IL-7Ralpha as a glucocorticoid-inducible gene. This observation was confirmed at the mRNA and protein levels. Conversely, TCR signaling decreased IL-7Ralpha expression, and the relative strength of signaling between these two receptors determined the final IL-7Ralpha levels. The up-regulation of IL-7Ralpha by glucocorticoids was associated with enhanced IL-7-mediated signaling and function. Moreover, IL-7-mediated inhibition of apoptosis at increasing concentrations of glucocorticoids is consistent with enhanced cell sensitivity to IL-7 following glucocorticoid exposure. These observations provide a mechanism by which glucocorticoids may have a positive influence on T cell survival and function." @default.
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- W1585617611 date "2002-03-01" @default.
- W1585617611 modified "2023-09-28" @default.
- W1585617611 title "Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor α" @default.
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- W1585617611 doi "https://doi.org/10.4049/jimmunol.168.5.2212" @default.
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