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- W1585655792 abstract "Malignant gliomas comprise a significant number of new cases of brain cancer diagnosed in the United States each year. Despite recent therapeutic advances, they remain associated with high morbidity and mortality rates. The current standard of care for newly diagnosed malignant gliomas includes surgical resection followed by radiotherapy with concomitant and adjuvant Temozolomide. Bevacizumab, a humanized anti-VEGF (vascular endothelial growth factor) monoclonal antibody, has recently gained FDA approval for use in the treatment of recurrent glioblastoma multiforme (GBM), based on clinical trials that revealed both efficacy and favorable side-effects. Anti-angiogenic therapy has raised new hopes, new basic and clinical questions, and has uncovered new insights into the biological and clinical behavior of these tumors. Here, we review the medical, social, and economic significance of gliomas, discuss briefly the evolution of therapeutic modalities leading to anti-angiogenesis, depict the basic mechanisms of angiogenesis, detail data from Bevacizumab clinical trials, and address new clinical issues leading to the revision of the Macdonald criteria. We close with unresolved questions and potential future directions." @default.
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- W1585655792 date "2011-09-22" @default.
- W1585655792 modified "2023-10-17" @default.
- W1585655792 title "Anti-Angiogenic Therapy for Malignant Glioma: Insights and Future Directions" @default.
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- W1585655792 doi "https://doi.org/10.5772/23021" @default.
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