FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1585800923> ?p ?o ?g. }

• W1585800923 abstract "A commercial Bacillus anthracis (Anthrax) whole genome protein microarray has been used to identify immunogenic Anthrax proteins using sera from groups of donors with (a) confirmed B. anthracis naturally acquired cutaneous infection, (b) confirmed B. anthracis intravenous drug use-acquired infection (c) occupational exposure in a wool-sorters factory (d) humans and rabbits vaccinated with the UK Anthrax protein vaccine and compared to naïve unexposed controls. Anti-IAP responses were observed for both IgG and IgA in the challenged groups; however the anti-IAP IgG response was more evident in the vaccinated group and the anti-IAP IgA response more evident in the B. anthracis-infected groups. Infected individuals appeared somewhat suppressed for their general IgG response, compared with other challenged groups. Immunogenic protein antigens were identified in all groups, some of which were shared between groups whilst others were specific for individual groups. The toxin proteins were immunodominant in all vaccinated, infected or other challenged groups. However a number of other chromosomally-located and plasmid encoded open reading frames were also recognised by infected or exposed groups in comparison to controls. Some of these antigens e.g. BA4182 are not recognised by vaccinated individuals, suggesting that there are proteins more specifically expressed by live Anthrax spores in vivo and are not currently found in the UK licensed Anthrax Vaccine (AVP). These may perhaps be preferentially expressed during infection and represent expression of alternative pathways in the B. anthracis ‘infectome’. These may make highly attractive candidates for diagnostic and vaccine biomarker development as they may be more specifically associated with the infectious phase of the pathogen. A number of B. anthracis small hypothetical protein targets have been synthesised, tested in mouse immunogenicity studies and validated in parallel using human sera from the same study." @default.
• W1585800923 created "2016-06-24" @default.
• W1585800923 creator A5004155088 @default.
• W1585800923 creator A5009753247 @default.
• W1585800923 creator A5024115924 @default.
• W1585800923 creator A5024795242 @default.
• W1585800923 creator A5025066877 @default.
• W1585800923 creator A5034478972 @default.
• W1585800923 creator A5036507773 @default.
• W1585800923 creator A5040702981 @default.
• W1585800923 creator A5047813836 @default.
• W1585800923 creator A5056337477 @default.
• W1585800923 creator A5057244834 @default.
• W1585800923 creator A5067555659 @default.
• W1585800923 creator A5079855257 @default.
• W1585800923 creator A5081994433 @default.
• W1585800923 date "2015-08-13" @default.
• W1585800923 modified "2023-09-25" @default.
• W1585800923 title "Whole genome protein microarrays for serum profiling of immunodominant antigens of Bacillus anthracis" @default.
• W1585800923 cites W100478810 @default.
• W1585800923 cites W107765342 @default.
• W1585800923 cites W113283106 @default.
• W1585800923 cites W13260432 @default.
• W1585800923 cites W1479973247 @default.
• W1585800923 cites W1709300913 @default.
• W1585800923 cites W1757308232 @default.
• W1585800923 cites W1765888134 @default.
• W1585800923 cites W1781813840 @default.
• W1585800923 cites W1827102232 @default.
• W1585800923 cites W1891338364 @default.
• W1585800923 cites W1968939990 @default.
• W1585800923 cites W1968977589 @default.
• W1585800923 cites W1977508498 @default.
• W1585800923 cites W1985212309 @default.
• W1585800923 cites W1997775622 @default.
• W1585800923 cites W2001808817 @default.
• W1585800923 cites W2007390574 @default.
• W1585800923 cites W2009980898 @default.
• W1585800923 cites W2011660547 @default.
• W1585800923 cites W2016635164 @default.
• W1585800923 cites W2016825203 @default.
• W1585800923 cites W2018931958 @default.
• W1585800923 cites W2024981220 @default.
• W1585800923 cites W2041722698 @default.
• W1585800923 cites W2046912993 @default.
• W1585800923 cites W2053168741 @default.
• W1585800923 cites W2054541213 @default.
• W1585800923 cites W2056341520 @default.
• W1585800923 cites W2063276338 @default.
• W1585800923 cites W2063736370 @default.
• W1585800923 cites W2064805825 @default.
• W1585800923 cites W2065991407 @default.
• W1585800923 cites W2069694209 @default.
• W1585800923 cites W2073663438 @default.
• W1585800923 cites W2087876070 @default.
• W1585800923 cites W2089372930 @default.
• W1585800923 cites W2095118652 @default.
• W1585800923 cites W2095233556 @default.
• W1585800923 cites W2098319691 @default.
• W1585800923 cites W2099725418 @default.
• W1585800923 cites W2100752818 @default.
• W1585800923 cites W2106786061 @default.
• W1585800923 cites W2106954995 @default.
• W1585800923 cites W2120106827 @default.
• W1585800923 cites W2122828763 @default.
• W1585800923 cites W2127344129 @default.
• W1585800923 cites W2128247100 @default.
• W1585800923 cites W2133457164 @default.
• W1585800923 cites W2134139258 @default.
• W1585800923 cites W2135069977 @default.
• W1585800923 cites W2140316735 @default.
• W1585800923 cites W2143347246 @default.
• W1585800923 cites W2152683563 @default.
• W1585800923 cites W2153073920 @default.
• W1585800923 cites W2154586372 @default.
• W1585800923 cites W2157709345 @default.
• W1585800923 cites W2162915355 @default.
• W1585800923 cites W2169461013 @default.
• W1585800923 cites W2170104986 @default.
• W1585800923 cites W2171162668 @default.
• W1585800923 cites W2263804876 @default.
• W1585800923 cites W2324519564 @default.
• W1585800923 cites W39751788 @default.
• W1585800923 cites W4232599696 @default.
• W1585800923 cites W4255260655 @default.
• W1585800923 cites W4300172357 @default.
• W1585800923 doi "https://doi.org/10.3389/fmicb.2015.00747" @default.
• W1585800923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4534840" @default.
• W1585800923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26322022" @default.
• W1585800923 hasPublicationYear "2015" @default.
• W1585800923 type Work @default.
• W1585800923 sameAs 1585800923 @default.
• W1585800923 citedByCount "9" @default.
• W1585800923 countsByYear W15858009232017 @default.
• W1585800923 countsByYear W15858009232018 @default.
• W1585800923 countsByYear W15858009232019 @default.
• W1585800923 countsByYear W15858009232020 @default.
• W1585800923 countsByYear W15858009232021 @default.
• W1585800923 crossrefType "journal-article" @default.
• W1585800923 hasAuthorship W1585800923A5004155088 @default.

• next