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- W1585854920 abstract "In this study, we successfully manufactured a new multifunctional drug delivery nanocapsule which was prepared through the electrostatic interactions between the CHC nanoparticles and pyranine, which formed a layer-by-layer (LBL) self-assembly nanocapsule (CHC-PY). Structural morphology of the pyranine-coated CHC nanoparticles was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM). And the mean size of CHC-PY was characterized by SEM and dynamic light scatter (DLS) measurements which demonstrated a pyranine concentration-dependent assembly size. The measurement of zeta-potential indicated that the charge of nanoparticles was reduced to be close to neutral and the size of increase after coating pyranine. The addition of pyranine shell would serve as a physical barrier to protect the drug and prolong drug release. The CHC-PY nanocapsule showed excellent encapsulation efficiency greater than 96% for an anti-cancer, hydrophobic molecule, (S)-(+)-Camptothecin (CPT). Additional study of the CHC to PY ratio on the nanoparticles and drug release rate revealed that CHC to PY ratio could manipulate the rate of drug release. We proved that CHC-PY nanocapsule had significantly enhanced CPT retention rate when compared to CHC-only nanocapsule. Finally, the CHC-PY nanocapsule also demonstrated outstanding biocompatibility in normal cell (IEC-6) and cancer cell (MCF-7 and A-549), as well as direct cellular-imaging.. The experimental results also showed that the CHC-PY to provide accurate and stable intracellular pH determination. To the above results suggest a promising vehicle for medical application." @default.
- W1585854920 created "2016-06-24" @default.
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- W1585854920 date "2011-01-01" @default.
- W1585854920 modified "2023-09-27" @default.
- W1585854920 title "酸鹼敏感型幾丁聚醣-甲氧基苄腈奈米殼核粒子應用於藥物輸送，細胞內顯影與酸鹼環境監測" @default.
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