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- W1585872414 endingPage "787" @default.
- W1585872414 startingPage "774" @default.
- W1585872414 abstract "Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. The pH-responsive PBAE component was chosen to promote endosome disruption, while the lipid surface layer was selected to minimize toxicity of the polycation core. Messenger RNA was efficiently adsorbed via electrostatic interactions onto the surface of these net positively charged nanoparticles. In vitro, mRNA-loaded particle uptake by dendritic cells led to mRNA delivery into the cytosol with low cytotoxicity, followed by translation of the encoded protein in these difficult-to-transfect cells at a frequency of ∼30%. Particles loaded with mRNA administered intranasally (i.n.) in mice led to the expression of the reporter protein luciferase in vivo as soon as 6 h after administration, a time point when naked mRNA given i.n. showed no expression. At later time points, luciferase expression was detected in naked mRNA-treated mice, but this group showed a wide variation in levels of transfection, compared to particle-treated mice. This system may thus be promising for noninvasive delivery of mRNA-based vaccines." @default.
- W1585872414 created "2016-06-24" @default.
- W1585872414 creator A5018291165 @default.
- W1585872414 creator A5028776474 @default.
- W1585872414 creator A5060454731 @default.
- W1585872414 creator A5087926553 @default.
- W1585872414 date "2011-04-01" @default.
- W1585872414 modified "2023-10-11" @default.
- W1585872414 title "<i>In Vitro</i> and <i>in Vivo</i> mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles" @default.
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