Matches in SemOpenAlex for { <https://semopenalex.org/work/W158589049> ?p ?o ?g. }
- W158589049 endingPage "28" @default.
- W158589049 startingPage "11" @default.
- W158589049 abstract "Primary brain tumors (PBT) are a pathologically diverse group of neoplasms that remain refractory to treatment. Gliomas are neoplasms of neuroepithelial origin that comprise the largest subgroup and most commonly diagnosed form of PBT. Gliomas usually demonstrate diffuse and infiltrative growth, especially high-grade varieties such as glioblastoma multiforme, anaplastic astrocytoma, and tumors of oligodendroglial origin. Surgical resection is the initial form of therapy for most patients with a PBT. A complete resection should be attempted for all low-grade tumors. For accessible high-grade lesions, gross-total resection of all enhancing tumor and regionally infiltrated brain should be considered. External beam fractionated irradiation should be administered to all patients with high-grade gliomas, and to selected patients with inaccessible or progressive low-grade PBT, especially if symptomatic or older than age 40. The standard regimen consists of 5000-6000 cGy administered in 180-200 cGy daily fractions over 5-7 weeks. Chemotherapy should be considered as adjunctive treatment for all malignant PBT and for selected low-grade gliomas. Temozolomide is an alkylating agent with a broad range of activity, which is often used in combination with irradiation, as well as in the adjuvant setting, for high-grade astrocytomas. Bevacizumab is a monoclonal antibody designed to target vascular endothelial growth factor, which has been shown to have activity against recurrent high-grade gliomas. Molecular therapeutic approaches are under development and have entered clinical trials." @default.
- W158589049 created "2016-06-24" @default.
- W158589049 creator A5019267884 @default.
- W158589049 creator A5068943487 @default.
- W158589049 date "2015-01-01" @default.
- W158589049 modified "2023-09-27" @default.
- W158589049 title "Overview of Epidemiology, Pathology, and Treatment of Primary Brain Tumors" @default.
- W158589049 cites W106348271 @default.
- W158589049 cites W1232974837 @default.
- W158589049 cites W1482109403 @default.
- W158589049 cites W1523734267 @default.
- W158589049 cites W1536266814 @default.
- W158589049 cites W1583926224 @default.
- W158589049 cites W1968710618 @default.
- W158589049 cites W1969656908 @default.
- W158589049 cites W1971674000 @default.
- W158589049 cites W1972804176 @default.
- W158589049 cites W1973027090 @default.
- W158589049 cites W1973952497 @default.
- W158589049 cites W1974714002 @default.
- W158589049 cites W1976638379 @default.
- W158589049 cites W1977392502 @default.
- W158589049 cites W1981289962 @default.
- W158589049 cites W1983200436 @default.
- W158589049 cites W1986718289 @default.
- W158589049 cites W1987644026 @default.
- W158589049 cites W2002816794 @default.
- W158589049 cites W2013897414 @default.
- W158589049 cites W2018163419 @default.
- W158589049 cites W2018612120 @default.
- W158589049 cites W2021239797 @default.
- W158589049 cites W2022268820 @default.
- W158589049 cites W2023879989 @default.
- W158589049 cites W2040596535 @default.
- W158589049 cites W2041532314 @default.
- W158589049 cites W2042270470 @default.
- W158589049 cites W2043126243 @default.
- W158589049 cites W2044403788 @default.
- W158589049 cites W2047624845 @default.
- W158589049 cites W2047979277 @default.
- W158589049 cites W2050287009 @default.
- W158589049 cites W2052066839 @default.
- W158589049 cites W2054745580 @default.
- W158589049 cites W2056236525 @default.
- W158589049 cites W2057783608 @default.
- W158589049 cites W2063919202 @default.
- W158589049 cites W2064214863 @default.
- W158589049 cites W2064325114 @default.
- W158589049 cites W2064735785 @default.
- W158589049 cites W2068740361 @default.
- W158589049 cites W2074823829 @default.
- W158589049 cites W2076747698 @default.
- W158589049 cites W2077368905 @default.
- W158589049 cites W2079150475 @default.
- W158589049 cites W2084451812 @default.
- W158589049 cites W2084859122 @default.
- W158589049 cites W2085724817 @default.
- W158589049 cites W2085892974 @default.
- W158589049 cites W2087328695 @default.
- W158589049 cites W2088925558 @default.
- W158589049 cites W2093062161 @default.
- W158589049 cites W2093084676 @default.
- W158589049 cites W2093334927 @default.
- W158589049 cites W2093783077 @default.
- W158589049 cites W2096287682 @default.
- W158589049 cites W2100075006 @default.
- W158589049 cites W2104878241 @default.
- W158589049 cites W2105431194 @default.
- W158589049 cites W2106011526 @default.
- W158589049 cites W2109606826 @default.
- W158589049 cites W2111229057 @default.
- W158589049 cites W2114994682 @default.
- W158589049 cites W2115690668 @default.
- W158589049 cites W2120077013 @default.
- W158589049 cites W2123748842 @default.
- W158589049 cites W2124736921 @default.
- W158589049 cites W2127745545 @default.
- W158589049 cites W2132482143 @default.
- W158589049 cites W2132697290 @default.
- W158589049 cites W2133616597 @default.
- W158589049 cites W213480149 @default.
- W158589049 cites W2135947790 @default.
- W158589049 cites W2139008103 @default.
- W158589049 cites W2147065885 @default.
- W158589049 cites W2149816876 @default.
- W158589049 cites W2152806275 @default.
- W158589049 cites W2153586130 @default.
- W158589049 cites W2153694112 @default.
- W158589049 cites W2153877097 @default.
- W158589049 cites W2156330848 @default.
- W158589049 cites W2158681922 @default.
- W158589049 cites W2159701773 @default.
- W158589049 cites W2161858905 @default.
- W158589049 cites W2162605078 @default.
- W158589049 cites W2166573361 @default.
- W158589049 cites W2167713837 @default.
- W158589049 cites W2168199397 @default.
- W158589049 cites W2168331385 @default.