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- W1585955360 abstract "Background: Warfarin sodium reduces stroke risk in patients with atrial fibrillation, but international normalized ratio (INR) monitoring is required. Target INRs are frequently not achieved, and the risk of death, bleeding, myocardial infarction (MI), and stroke or systemic embolism event (SEE) may be related to INR control. Methods: We analyzed the relationship between INR control and the rates of death, bleeding, MI, and stroke or SEE among 3587 patients with atrial fibrillation randomized to receive warfarin treatment in the SPORTIF (Stroke Prevention Using an Oral Thrombin Inhibitor in Atrial Fibrillation) III and V trials. The mean±SD follow-up was 16.6±6.3 months. Patients were divided into 3 equal groups (those with good control [75%], those with moderate control [60%-75%], or those with poor control [60%]) according to the percentage time with an INR of 2.0 to 3.0. Outcomes were compared according to INR control. The main outcome measures were death, bleeding, MI, and stroke or SEE. Results:The poor control group had higher rates of annualmortality(4.20%)andmajorbleeding(3.85%)comparedwiththemoderatecontrolgroup(1.84%and1.96%, respectively) and the good control group (1.69% and 1.58%, respectively) (P.01 for all). Compared with the good control group, the poor control group had higher ratesofMI(1.38%vs0.62%,P=.04)andofstrokeorSEE (2.10% vs 1.07%, P=.02). Conclusions: In patients with atrial fibrillation taking warfarin,therisksofdeath,MI,majorbleeding,andstroke or SEE are related to INR control. Good INR control is important to improve patient outcomes." @default.
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- W1585955360 date "2017-01-01" @default.
- W1585955360 modified "2023-09-27" @default.
- W1585955360 title "Comparison of Outcomes Among Patients Randomized to Warfarin Therapy According to Anticoagulant Control" @default.
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