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- W1585963501 abstract "We have demonstrated previously that 1-beta-D-arabinofuranosylcytosine (ara-C) incorporates specifically in cellular DNA and that the formation of (ara-C)DNA correlates significantly with inhibition of DNA synthesis and loss of clonogenic survival. Similar results have been obtained with 9-beta-D-arabinofuranosyl-adenine (ara-A). These findings have been extended by studying the incorporation of ara-C in DNA of a wild-type herpes simplex virus (HSV) and a mutant virus resistant to ara-C and ara-A. The results demonstrate that HSV resistance to ara-A is associated with formation of less (ara-C)DNA and less inhibition of DNA synthesis when compared to wild-type virus. This effect on formation of (ara-C)DNA is reversed upon exposure to higher (greater than 10(-6) M) ara-C concentrations, and this pattern of resistance corresponds to drug effect on virus plaque formation. The results also demonstrate a highly significant relationship between incorporation of ara-C in HSV DNA and inhibition of DNA synthesis for both viruses. Further, higher concentrations of ara-C that result in greater inhibition of DNA synthesis are associated with an increasing number of ara-C residues at the 3'-terminus of the DNA strand, thus suggesting that ara-C functions as a poor primer terminus for viral chain elongation. These results also suggest that HSV cross-resistance to ara-A and ara-C may be related to an altered viral DNA polymerase and that incorporation of ara-C in HSV DNA is at least one mechanism responsible for slowing viral synthesis and inducing lethal events." @default.
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- W1585963501 date "1984-01-01" @default.
- W1585963501 modified "2023-09-23" @default.
- W1585963501 title "Incorporation of 1-beta-D-arabinofuranosylcytosine into DNA from herpes simplex virus resistant to 9-beta-D-arabinofuranosyladenine." @default.
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