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- W1586006306 abstract "The discovery of host-encoded gene products that sense molecular patterns in infectious microbes, and the demonstration of their role in triggering innate and adaptive immune responses, has been a key milestone in our understanding of immunology. Twenty-three years after Janeway first outlined the fundamental concepts of the 'pattern recognition' model, and 15 years since the identification of Toll-like receptors (TLRs) as pattern recognition receptors (PRRs), new insights continue to be revealed, and questions remain. For example, innate immune responses to microbes that are mediated by PRRs have historically been viewed as the domain of innate immune cell populations such as dendritic cells and macrophages. New evidence, however, has pointed to the role of B-cell-intrinsic TLR activation in shaping antibody responses. These studies have revealed that TLRs regulate a complex transcriptional network that controls multiple steps in the development of antigen-specific antibodies. This review covers these recent developments regarding the role of TLRs in B-cell gene expression and function in vitro and in vivo, and highlights the remaining challenges in the field, with particular emphasis on the role of TLRs in antibody responses to viral infection. A more complete understanding of how TLRs regulate antibody responses will lead to improved vaccine design." @default.
- W1586006306 created "2016-06-24" @default.
- W1586006306 creator A5019614564 @default.
- W1586006306 date "2012-07-02" @default.
- W1586006306 modified "2023-10-18" @default.
- W1586006306 title "Regulation of B-cell responses by Toll-like receptors" @default.
- W1586006306 cites W1483162601 @default.
- W1586006306 cites W1491192294 @default.
- W1586006306 cites W1514339684 @default.
- W1586006306 cites W1514540900 @default.
- W1586006306 cites W1519633296 @default.
- W1586006306 cites W1525912444 @default.
- W1586006306 cites W1531681105 @default.
- W1586006306 cites W1534496719 @default.
- W1586006306 cites W1598212950 @default.
- W1586006306 cites W1614256433 @default.
- W1586006306 cites W1674878436 @default.
- W1586006306 cites W1718070417 @default.
- W1586006306 cites W1757731638 @default.
- W1586006306 cites W1798949989 @default.
- W1586006306 cites W1820258609 @default.
- W1586006306 cites W1876204943 @default.
- W1586006306 cites W1882673640 @default.
- W1586006306 cites W1918941126 @default.
- W1586006306 cites W1919093559 @default.
- W1586006306 cites W1934712179 @default.
- W1586006306 cites W1968021766 @default.
- W1586006306 cites W1971799655 @default.
- W1586006306 cites W1976853865 @default.
- W1586006306 cites W1980273234 @default.
- W1586006306 cites W1981295756 @default.
- W1586006306 cites W1986097339 @default.
- W1586006306 cites W1994391392 @default.
- W1586006306 cites W1995045831 @default.
- W1586006306 cites W1995866508 @default.
- W1586006306 cites W1999578911 @default.
- W1586006306 cites W2001039642 @default.
- W1586006306 cites W2001988677 @default.
- W1586006306 cites W2004887151 @default.
- W1586006306 cites W2005634587 @default.
- W1586006306 cites W2006614062 @default.
- W1586006306 cites W2007222211 @default.
- W1586006306 cites W2007710074 @default.
- W1586006306 cites W2008152503 @default.
- W1586006306 cites W2008826892 @default.
- W1586006306 cites W2008866474 @default.
- W1586006306 cites W2011211995 @default.
- W1586006306 cites W2015564999 @default.
- W1586006306 cites W2018722698 @default.
- W1586006306 cites W2024852380 @default.
- W1586006306 cites W2025412364 @default.
- W1586006306 cites W2026563152 @default.
- W1586006306 cites W2027401883 @default.
- W1586006306 cites W2027890164 @default.
- W1586006306 cites W2028575270 @default.
- W1586006306 cites W2028682232 @default.
- W1586006306 cites W2029320721 @default.
- W1586006306 cites W2030611349 @default.
- W1586006306 cites W2032966566 @default.
- W1586006306 cites W2034450834 @default.
- W1586006306 cites W2034708798 @default.
- W1586006306 cites W2042306200 @default.
- W1586006306 cites W2042732565 @default.
- W1586006306 cites W2043106142 @default.
- W1586006306 cites W2045465609 @default.
- W1586006306 cites W2045753854 @default.
- W1586006306 cites W2047865956 @default.
- W1586006306 cites W2048865828 @default.
- W1586006306 cites W2049404127 @default.
- W1586006306 cites W2050818336 @default.
- W1586006306 cites W2055754872 @default.
- W1586006306 cites W2057832232 @default.
- W1586006306 cites W2058536807 @default.
- W1586006306 cites W2061072930 @default.
- W1586006306 cites W2061203855 @default.
- W1586006306 cites W2065694999 @default.
- W1586006306 cites W2066360207 @default.
- W1586006306 cites W2070727054 @default.
- W1586006306 cites W2071162967 @default.
- W1586006306 cites W2073489229 @default.
- W1586006306 cites W2075152942 @default.
- W1586006306 cites W2076361525 @default.
- W1586006306 cites W2078811876 @default.
- W1586006306 cites W2081291921 @default.
- W1586006306 cites W2082736230 @default.
- W1586006306 cites W2083829960 @default.
- W1586006306 cites W2084603524 @default.
- W1586006306 cites W2087863438 @default.
- W1586006306 cites W2089905475 @default.
- W1586006306 cites W2090602346 @default.
- W1586006306 cites W2092157690 @default.
- W1586006306 cites W2098070967 @default.
- W1586006306 cites W2102097271 @default.
- W1586006306 cites W2108407626 @default.
- W1586006306 cites W2110161909 @default.
- W1586006306 cites W2110853277 @default.
- W1586006306 cites W2111200149 @default.
- W1586006306 cites W2113236498 @default.