FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1586014874> ?p ?o ?g. }

• W1586014874 endingPage "395" @default.
• W1586014874 startingPage "386" @default.
• W1586014874 abstract "Nationally, nearly 1.5 million patients in the USA suffer from ailments requiring bone grafts and hip and other joint replacements. Infections following internal fixation in orthopaedic trauma can cause osteomyelitis in 22-66% of cases and, if uncontrolled, the mortality rate can be as high as 2%. We characterize a procedure for the synthesis of antimicrobial and biocompatible poly-l-lactic acid (PLLA) and poly-ethyleneglycol (PEG) bioscaffolds designed to degrade and absorb at a controlled rate. The bioscaffold architecture aims to provide a suitable substrate for the controlled release of silver nanoparticles (SNPs) to reduce bacterial growth and to aid the proliferation of human adipose-derived stem cells (hASCs) for tissue-engineering applications. The fabricated bioscaffolds were characterized by scanning transmission microscope (SEM) and it showed that the addition of tncreasing concentrations of SNPs results in the formation of dendritic porous channels perpendicular to the axis of precipitation. The antimicrobial properties of these porous bioscaffolds were tested according to a modified ISO 22196 standard across varying concentrations of biomass-mediated SNPs to determine an efficacious antimicrobial concentration. The bioscaffolds reduced the Staphylococcus aureus and Escherichia coli viable colony-forming units by 98.85% and 99.9%, respectively, at an antimicrobial SNPs concentration of 2000 ppm. Human ASCs were seeded on bioscaffolds and cultured in vitro for 20 days to study the effect of SNPs concentration on the viability of cells. SEM analysis and the metabolic activity-based fluorescent dye, AlamarBlue®, demonstrated the growth of cells on the efficacious antimicrobial bioscaffolds. The biocompatibility of in vitro leached silver, quantified by inductively coupled plasma optical emission spectroscopy (ICP-OES), proved non-cytotoxic when tested against hASCs, as evaluated by MTT assay." @default.
• W1586014874 created "2016-06-24" @default.
• W1586014874 creator A5003368771 @default.
• W1586014874 creator A5022450437 @default.
• W1586014874 creator A5026038537 @default.
• W1586014874 creator A5032505330 @default.
• W1586014874 creator A5041271640 @default.
• W1586014874 creator A5071653812 @default.
• W1586014874 creator A5072141508 @default.
• W1586014874 date "2012-06-15" @default.
• W1586014874 modified "2023-09-27" @default.
• W1586014874 title "Antimicrobial biocompatible bioscaffolds for orthopaedic implants" @default.
• W1586014874 cites W1895042802 @default.
• W1586014874 cites W1968148722 @default.
• W1586014874 cites W1979125069 @default.
• W1586014874 cites W1980757056 @default.
• W1586014874 cites W1982430942 @default.
• W1586014874 cites W1985736724 @default.
• W1586014874 cites W1987363649 @default.
• W1586014874 cites W1997208333 @default.
• W1586014874 cites W2014560473 @default.
• W1586014874 cites W2020569475 @default.
• W1586014874 cites W2021964978 @default.
• W1586014874 cites W2025234097 @default.
• W1586014874 cites W2025663730 @default.
• W1586014874 cites W2031031669 @default.
• W1586014874 cites W2034552025 @default.
• W1586014874 cites W2041786566 @default.
• W1586014874 cites W2047420544 @default.
• W1586014874 cites W2056833999 @default.
• W1586014874 cites W2062740063 @default.
• W1586014874 cites W2075573882 @default.
• W1586014874 cites W2080161301 @default.
• W1586014874 cites W2089434672 @default.
• W1586014874 cites W2093222176 @default.
• W1586014874 cites W2093750972 @default.
• W1586014874 cites W2095560028 @default.
• W1586014874 cites W2113042424 @default.
• W1586014874 cites W2120791646 @default.
• W1586014874 cites W2126832734 @default.
• W1586014874 cites W2142720627 @default.
• W1586014874 cites W2163297744 @default.
• W1586014874 doi "https://doi.org/10.1002/term.1532" @default.
• W1586014874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22700366" @default.
• W1586014874 hasPublicationYear "2012" @default.
• W1586014874 type Work @default.
• W1586014874 sameAs 1586014874 @default.
• W1586014874 citedByCount "23" @default.
• W1586014874 countsByYear W15860148742013 @default.
• W1586014874 countsByYear W15860148742014 @default.
• W1586014874 countsByYear W15860148742015 @default.
• W1586014874 countsByYear W15860148742016 @default.
• W1586014874 countsByYear W15860148742017 @default.
• W1586014874 countsByYear W15860148742018 @default.
• W1586014874 countsByYear W15860148742019 @default.
• W1586014874 countsByYear W15860148742020 @default.
• W1586014874 countsByYear W15860148742021 @default.
• W1586014874 countsByYear W15860148742022 @default.
• W1586014874 crossrefType "journal-article" @default.
• W1586014874 hasAuthorship W1586014874A5003368771 @default.
• W1586014874 hasAuthorship W1586014874A5022450437 @default.
• W1586014874 hasAuthorship W1586014874A5026038537 @default.
• W1586014874 hasAuthorship W1586014874A5032505330 @default.
• W1586014874 hasAuthorship W1586014874A5041271640 @default.
• W1586014874 hasAuthorship W1586014874A5071653812 @default.
• W1586014874 hasAuthorship W1586014874A5072141508 @default.
• W1586014874 hasBestOaLocation W15860148741 @default.
• W1586014874 hasConcept C136229726 @default.
• W1586014874 hasConcept C185592680 @default.
• W1586014874 hasConcept C191897082 @default.
• W1586014874 hasConcept C192562407 @default.
• W1586014874 hasConcept C2777230088 @default.
• W1586014874 hasConcept C4937899 @default.
• W1586014874 hasConcept C49892992 @default.
• W1586014874 hasConcept C71924100 @default.
• W1586014874 hasConcept C86803240 @default.
• W1586014874 hasConcept C89423630 @default.
• W1586014874 hasConceptScore W1586014874C136229726 @default.
• W1586014874 hasConceptScore W1586014874C185592680 @default.
• W1586014874 hasConceptScore W1586014874C191897082 @default.
• W1586014874 hasConceptScore W1586014874C192562407 @default.
• W1586014874 hasConceptScore W1586014874C2777230088 @default.
• W1586014874 hasConceptScore W1586014874C4937899 @default.
• W1586014874 hasConceptScore W1586014874C49892992 @default.
• W1586014874 hasConceptScore W1586014874C71924100 @default.
• W1586014874 hasConceptScore W1586014874C86803240 @default.
• W1586014874 hasConceptScore W1586014874C89423630 @default.
• W1586014874 hasIssue "5" @default.
• W1586014874 hasLocation W15860148741 @default.
• W1586014874 hasLocation W15860148742 @default.
• W1586014874 hasOpenAccess W1586014874 @default.
• W1586014874 hasPrimaryLocation W15860148741 @default.
• W1586014874 hasRelatedWork W2025911684 @default.
• W1586014874 hasRelatedWork W2028744988 @default.
• W1586014874 hasRelatedWork W2350003174 @default.
• W1586014874 hasRelatedWork W2358093696 @default.
• W1586014874 hasRelatedWork W2362484625 @default.
• W1586014874 hasRelatedWork W2371122115 @default.

• next