Matches in SemOpenAlex for { <https://semopenalex.org/work/W1586178092> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W1586178092 endingPage "87S" @default.
- W1586178092 startingPage "82S" @default.
- W1586178092 abstract "Congestive heart failure (CHF) causes disabling symptoms and increases the likelihood of decreased survival. Diuretics, direct vasodilators, and angiotensin-converting enzyme (ACE) inhibitors can be used to reduce symptoms, prolong life, or both, in these individuals. Diuretics induce sodium and water excretion, leading to decreased cardiac preload and wall tension, and an effective decrease of symptomatic pulmonary and systemic congestion. They have not yet been shown to prolong life in patients with CHF, however. Direct vasodilators, which induce venodilation, arterial dilation, or both (balanced vasodilators), may improve symptoms, and some but not all prolong life. Venodilators, such as nitrates, exert a venous pooling effect, decreasing cardiac preload and symptoms of congestion. Arterial dilators, such as hydralazine, decrease afterload and improve cardiac output. The combination of hydralazine and isosorbide dinitrate provides balanced vasodilation. It also improves survival, but is associated with a relatively high frequency of side effects necessitating discontinuation of one or both agents. The drugs are not approved by the Food and Drug Administration for the treatment of heart failure. Flosequinan, a new orally administered, long-acting, balanced arteriovenous dilator, improves exercise tolerance and symptoms. However, preliminary analysis of data from a large, multicenter trial revealed increased mortality and hospitalization for worsening CHF. The drug has recently been withdrawn from the market. The ACE inhibitors can cause hemodynamic and neurohormonal changes that lead to a reduction of preload and afterload, decreasing symptoms of heart failure. They significantly decrease CHF mortality, and might also deter the development of overt heart failure in some asymptomatic patients with left ventricular dysfunction." @default.
- W1586178092 created "2016-06-24" @default.
- W1586178092 creator A5059925734 @default.
- W1586178092 date "1993-09-01" @default.
- W1586178092 modified "2023-09-23" @default.
- W1586178092 title "Assessing the treatment of congestive heart failure: diuretics, vasodilators, and angiotensin-converting enzyme inhibitors." @default.
- W1586178092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8233997" @default.
- W1586178092 hasPublicationYear "1993" @default.
- W1586178092 type Work @default.
- W1586178092 sameAs 1586178092 @default.
- W1586178092 citedByCount "6" @default.
- W1586178092 countsByYear W15861780922019 @default.
- W1586178092 countsByYear W15861780922020 @default.
- W1586178092 countsByYear W15861780922022 @default.
- W1586178092 crossrefType "journal-article" @default.
- W1586178092 hasAuthorship W1586178092A5059925734 @default.
- W1586178092 hasConcept C120770815 @default.
- W1586178092 hasConcept C123576724 @default.
- W1586178092 hasConcept C126322002 @default.
- W1586178092 hasConcept C164705383 @default.
- W1586178092 hasConcept C178853913 @default.
- W1586178092 hasConcept C2778198053 @default.
- W1586178092 hasConcept C2778949068 @default.
- W1586178092 hasConcept C2780521442 @default.
- W1586178092 hasConcept C48277249 @default.
- W1586178092 hasConcept C71924100 @default.
- W1586178092 hasConcept C84393581 @default.
- W1586178092 hasConceptScore W1586178092C120770815 @default.
- W1586178092 hasConceptScore W1586178092C123576724 @default.
- W1586178092 hasConceptScore W1586178092C126322002 @default.
- W1586178092 hasConceptScore W1586178092C164705383 @default.
- W1586178092 hasConceptScore W1586178092C178853913 @default.
- W1586178092 hasConceptScore W1586178092C2778198053 @default.
- W1586178092 hasConceptScore W1586178092C2778949068 @default.
- W1586178092 hasConceptScore W1586178092C2780521442 @default.
- W1586178092 hasConceptScore W1586178092C48277249 @default.
- W1586178092 hasConceptScore W1586178092C71924100 @default.
- W1586178092 hasConceptScore W1586178092C84393581 @default.
- W1586178092 hasIssue "5 Pt 2" @default.
- W1586178092 hasLocation W15861780921 @default.
- W1586178092 hasOpenAccess W1586178092 @default.
- W1586178092 hasPrimaryLocation W15861780921 @default.
- W1586178092 hasRelatedWork W1586178092 @default.
- W1586178092 hasRelatedWork W1978094107 @default.
- W1586178092 hasRelatedWork W1980329571 @default.
- W1586178092 hasRelatedWork W2014066484 @default.
- W1586178092 hasRelatedWork W2035092627 @default.
- W1586178092 hasRelatedWork W2046510447 @default.
- W1586178092 hasRelatedWork W2121825659 @default.
- W1586178092 hasRelatedWork W2152013327 @default.
- W1586178092 hasRelatedWork W2412862343 @default.
- W1586178092 hasRelatedWork W2470256234 @default.
- W1586178092 hasVolume "13" @default.
- W1586178092 isParatext "false" @default.
- W1586178092 isRetracted "false" @default.
- W1586178092 magId "1586178092" @default.
- W1586178092 workType "article" @default.