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• W1586337736 abstract "Polyether ionophore antibiotics are a special class of polyketides widely used in veterinary medicine, and as food additives in animal husbandry. In this article, we review current knowledge about the mechanism of polyether biosynthesis, and the genetic and biochemical strategies used for its study. Several clear differences distinguish it from traditional type I modular polyketide biosynthesis: polyether backbones are assembled by modular polyketide synthases but are modified by two key enzymes, epoxidase and epoxide hydrolase, to generate the product. All double bonds involved in the oxidative cyclization in the polyketide backbone are of E geometry. Chain release in the polyether biosynthetic pathway requires a special type II thioesterase which specifically hydrolyzes the polyether thioester. All these discoveries should be very helpful for a deep understanding of the biosynthetic mechanism of this class of important natural compounds, and for the targeted engineering of polyether derivatives." @default.
• W1586337736 created "2016-06-24" @default.
• W1586337736 creator A5010932917 @default.
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• W1586337736 date "2009-01-01" @default.
• W1586337736 modified "2023-10-09" @default.
• W1586337736 title "Chapter 9 The Enzymology of Polyether Biosynthesis" @default.
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• W1586337736 doi "https://doi.org/10.1016/s0076-6879(09)04609-6" @default.
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• W1586337736 hasPublicationYear "2009" @default.
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