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- W1586391285 endingPage "126" @default.
- W1586391285 startingPage "91" @default.
- W1586391285 abstract "In recent years, stem cells have shown significant promise for their potential to provide a source of undifferentiated progenitor cells for therapeutic applications in tissue or organ repair. Significant questions still remain, however, as to the genetic and epigenetic signals that regulate the fate of stem cells. It is now well accepted that the micro-environment of the stem cell can have a significant influence on its differentiation and phenotypic expression. Although emphasis has been placed in previous work on the role of soluble mediators such as growth factors and cytokines on stem cell differentiation, there is now significant evidence, both direct and indirect, that mechanical signals may also regulate stem cell fate. We review a number of in vivo and in vitro studies that have provided evidence that mechanical factors have the ability to influence the differentiation of a number of cells that have been classified as either precursor, progenitor, or stem cells. Taken together, these studies show that specific mechanical signals may promote cell differentiation into a particular phenotype, potentially having an effect on embryonic development. The use of such mechanical signals in vitro in specially designed bioreactors may provide important adjuncts to standard biochemical signaling pathways for promoting engineered tissue growth. A further understanding of the biomechanical and biochemical pathways involved in mechanical signal transduction by stem cells will hopefully provide new insight for the improvement of stem-cell based therapies." @default.
- W1586391285 created "2016-06-24" @default.
- W1586391285 creator A5021081883 @default.
- W1586391285 creator A5026038537 @default.
- W1586391285 creator A5090627153 @default.
- W1586391285 date "2004-01-01" @default.
- W1586391285 modified "2023-09-26" @default.
- W1586391285 title "Mechanical Signals as Regulators of Stem Cell Fate" @default.
- W1586391285 cites W1537898230 @default.
- W1586391285 cites W1540740268 @default.
- W1586391285 cites W1544751778 @default.
- W1586391285 cites W1559409985 @default.
- W1586391285 cites W1784155883 @default.
- W1586391285 cites W1805716398 @default.
- W1586391285 cites W182299618 @default.
- W1586391285 cites W1902864351 @default.
- W1586391285 cites W1932241391 @default.
- W1586391285 cites W1946911025 @default.
- W1586391285 cites W1965415256 @default.
- W1586391285 cites W1966462125 @default.
- W1586391285 cites W1968222609 @default.
- W1586391285 cites W1972192103 @default.
- W1586391285 cites W1973773236 @default.
- W1586391285 cites W1975621622 @default.
- W1586391285 cites W1977950302 @default.
- W1586391285 cites W1990539824 @default.
- W1586391285 cites W1991415492 @default.
- W1586391285 cites W1994596418 @default.
- W1586391285 cites W1995039844 @default.
- W1586391285 cites W1995091382 @default.
- W1586391285 cites W1996647995 @default.
- W1586391285 cites W1999312713 @default.
- W1586391285 cites W1999639777 @default.
- W1586391285 cites W2000904875 @default.
- W1586391285 cites W2001783191 @default.
- W1586391285 cites W2004710891 @default.
- W1586391285 cites W2005534446 @default.
- W1586391285 cites W2011810078 @default.
- W1586391285 cites W2014281402 @default.
- W1586391285 cites W2017909742 @default.
- W1586391285 cites W2019562501 @default.
- W1586391285 cites W2019730808 @default.
- W1586391285 cites W2024828272 @default.
- W1586391285 cites W2024969521 @default.
- W1586391285 cites W2026342262 @default.
- W1586391285 cites W2027740838 @default.
- W1586391285 cites W2028697025 @default.
- W1586391285 cites W2028704032 @default.
- W1586391285 cites W2029610877 @default.
- W1586391285 cites W2035170119 @default.
- W1586391285 cites W2036165258 @default.
- W1586391285 cites W2036289981 @default.
- W1586391285 cites W2036748347 @default.
- W1586391285 cites W2037446157 @default.
- W1586391285 cites W2038876977 @default.
- W1586391285 cites W2040845651 @default.
- W1586391285 cites W2040873162 @default.
- W1586391285 cites W2041052365 @default.
- W1586391285 cites W2042738198 @default.
- W1586391285 cites W2043238627 @default.
- W1586391285 cites W2053002098 @default.
- W1586391285 cites W2055881093 @default.
- W1586391285 cites W2057346422 @default.
- W1586391285 cites W2058504739 @default.
- W1586391285 cites W2059107467 @default.
- W1586391285 cites W2059668536 @default.
- W1586391285 cites W2060608295 @default.
- W1586391285 cites W2064879706 @default.
- W1586391285 cites W2065355357 @default.
- W1586391285 cites W2070466054 @default.
- W1586391285 cites W2070515774 @default.
- W1586391285 cites W2074870817 @default.
- W1586391285 cites W2075835663 @default.
- W1586391285 cites W2076074245 @default.
- W1586391285 cites W2080356858 @default.
- W1586391285 cites W2081784335 @default.
- W1586391285 cites W2083319499 @default.
- W1586391285 cites W2084687998 @default.
- W1586391285 cites W2085697345 @default.
- W1586391285 cites W2087255769 @default.
- W1586391285 cites W2087457097 @default.
- W1586391285 cites W2087913473 @default.
- W1586391285 cites W2088670027 @default.
- W1586391285 cites W2090878767 @default.
- W1586391285 cites W2092658506 @default.
- W1586391285 cites W2093413490 @default.
- W1586391285 cites W2097767628 @default.
- W1586391285 cites W2101245520 @default.
- W1586391285 cites W2107503723 @default.
- W1586391285 cites W2108956625 @default.
- W1586391285 cites W2119882428 @default.
- W1586391285 cites W2125272276 @default.
- W1586391285 cites W2125797096 @default.
- W1586391285 cites W2127300454 @default.
- W1586391285 cites W2127905508 @default.
- W1586391285 cites W2137080510 @default.
- W1586391285 cites W2138094668 @default.
- W1586391285 cites W2145006455 @default.