FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W158644536> ?p ?o ?g. }

• W158644536 endingPage "32" @default.
• W158644536 startingPage "25" @default.
• W158644536 abstract "Cysteine sulfinate decarboxylase (CSD) is thought to be the rate limiting step of taurine biosynthesis9. It may thus represent a key enzyme in the function of taurine. While a CSD activity was detected in crude brain extracts more than four decades ago, its identification, characterization and cellular localization in brain proved difficult and led to controversial reports (For review see14,15). We previously established that there exists in brain an enzyme showing a strong affinity and narrow specificity for cysteine sulfinic acid (CSA) and cysteic acid (CA)6. Brain CSD appeared to be very similar to the CSD from liver: both proteins have similar physico-chemical and enzymatic properties3,6 and share common antigenic epitopes9. Using a specific antiserum against liver CSD1 we showed that CSD immunopositive cells in hippocampus and cerebellum were astrocytes through a quantitative double immunofluorescence analysis with appropriate astroglial markers11. In rat brain, CSD expression level reveals two distinct phenotypes in astrocytes that exhibit a different distribution pattern10. Given that taurine was reported to be localized predominantly in neurons5,8, our findings suggest that the poorly understood functional role of taurine in the brain4,7 should be investigated within the framework of astrocyte-neuron interactions. In addition, our results suggest that the CSD expression level may vary greatly among astrocytes according to their location and functional state. Disclosing the regulation of the genomic expression of CSD in various experimental situations could help provide insight into the physiological role of taurine in the brain. With this long-term goal in mind, we have carried out molecular cloning of CSD12, determined its sequence and developed new appropriate tools, such as the quantification of CSD-mRNA through competitive reverse transcription coupled with polymerase chain reaction (RT-PCR). These molecular biology techniques will enable us to investigate the regulation of the genomic expression of CSD in brain, as well as in astrocytes in primary culture." @default.
• W158644536 created "2016-06-24" @default.
• W158644536 creator A5004751338 @default.
• W158644536 creator A5023265145 @default.
• W158644536 creator A5041944987 @default.
• W158644536 creator A5070373871 @default.
• W158644536 date "1998-01-01" @default.
• W158644536 modified "2023-09-25" @default.
• W158644536 title "Cysteine Sulfinate Decarboxylase (CSD): Molecular Cloning, Sequence and Genomic Expression in Brain" @default.
• W158644536 cites W1562603203 @default.
• W158644536 cites W1969992365 @default.
• W158644536 cites W1985931825 @default.
• W158644536 cites W1993372741 @default.
• W158644536 cites W2010947990 @default.
• W158644536 cites W2017591430 @default.
• W158644536 cites W2054154019 @default.
• W158644536 cites W2060005442 @default.
• W158644536 cites W2062597482 @default.
• W158644536 cites W2082329019 @default.
• W158644536 cites W2082849695 @default.
• W158644536 cites W2089009923 @default.
• W158644536 cites W92337530 @default.
• W158644536 doi "https://doi.org/10.1007/978-1-4899-0117-0_4" @default.
• W158644536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9635011" @default.
• W158644536 hasPublicationYear "1998" @default.
• W158644536 type Work @default.
• W158644536 sameAs 158644536 @default.
• W158644536 citedByCount "6" @default.
• W158644536 countsByYear W1586445362012 @default.
• W158644536 countsByYear W1586445362015 @default.
• W158644536 crossrefType "book-chapter" @default.
• W158644536 hasAuthorship W158644536A5004751338 @default.
• W158644536 hasAuthorship W158644536A5023265145 @default.
• W158644536 hasAuthorship W158644536A5041944987 @default.
• W158644536 hasAuthorship W158644536A5070373871 @default.
• W158644536 hasConcept C169760540 @default.
• W158644536 hasConcept C181199279 @default.
• W158644536 hasConcept C185592680 @default.
• W158644536 hasConcept C2776880858 @default.
• W158644536 hasConcept C2777542381 @default.
• W158644536 hasConcept C2777608289 @default.
• W158644536 hasConcept C2779201268 @default.
• W158644536 hasConcept C2779652256 @default.
• W158644536 hasConcept C2779701627 @default.
• W158644536 hasConcept C515207424 @default.
• W158644536 hasConcept C529278444 @default.
• W158644536 hasConcept C55493867 @default.
• W158644536 hasConcept C86803240 @default.
• W158644536 hasConcept C95444343 @default.
• W158644536 hasConceptScore W158644536C169760540 @default.
• W158644536 hasConceptScore W158644536C181199279 @default.
• W158644536 hasConceptScore W158644536C185592680 @default.
• W158644536 hasConceptScore W158644536C2776880858 @default.
• W158644536 hasConceptScore W158644536C2777542381 @default.
• W158644536 hasConceptScore W158644536C2777608289 @default.
• W158644536 hasConceptScore W158644536C2779201268 @default.
• W158644536 hasConceptScore W158644536C2779652256 @default.
• W158644536 hasConceptScore W158644536C2779701627 @default.
• W158644536 hasConceptScore W158644536C515207424 @default.
• W158644536 hasConceptScore W158644536C529278444 @default.
• W158644536 hasConceptScore W158644536C55493867 @default.
• W158644536 hasConceptScore W158644536C86803240 @default.
• W158644536 hasConceptScore W158644536C95444343 @default.
• W158644536 hasLocation W1586445361 @default.
• W158644536 hasLocation W1586445362 @default.
• W158644536 hasOpenAccess W158644536 @default.
• W158644536 hasPrimaryLocation W1586445361 @default.
• W158644536 hasRelatedWork W118582635 @default.
• W158644536 hasRelatedWork W158644536 @default.
• W158644536 hasRelatedWork W2079358172 @default.
• W158644536 hasRelatedWork W2169115330 @default.
• W158644536 hasRelatedWork W2333162751 @default.
• W158644536 hasRelatedWork W2463837802 @default.
• W158644536 hasRelatedWork W2771220159 @default.
• W158644536 hasRelatedWork W3084531528 @default.
• W158644536 hasRelatedWork W92337530 @default.
• W158644536 hasRelatedWork W2070911357 @default.
• W158644536 isParatext "false" @default.
• W158644536 isRetracted "false" @default.
• W158644536 magId "158644536" @default.
• W158644536 workType "book-chapter" @default.