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- W1586501510 abstract "For several decades it has been known that mental retardation is associated with abnormalities in dendrites and dendritic spines. The recent cloning of eight genes which cause nonspecific mental retardation when mutated, provides an important insight into the cellular mechanisms that result in the dendritic abnormalities underlying mental retardation. Three of the encoded proteins, oligophrenin1, PAK3 and αPix, interact directly with Rho GTPases. Rho GTPases are key signaling proteins which integrate extracellular and intracellular signals to orchestrate coordinated changes in the actin cytoskeleton, essential for directed neurite outgrowth and the generation/rearrangement of synaptic connectivity. Although many details of the cell biology of Rho signaling in the CNS are as yet unclear, a picture is unfolding showing how mutations that cause abnormal Rho signaling result in abnormal neuronal connectivity which gives rise to deficient cognitive functioning in humans." @default.
- W1586501510 created "2016-06-24" @default.
- W1586501510 creator A5014003507 @default.
- W1586501510 creator A5045529956 @default.
- W1586501510 date "2005-01-01" @default.
- W1586501510 modified "2023-09-26" @default.
- W1586501510 title "Rho proteins, mental retardation and the neurobiological basis of intelligence" @default.
- W1586501510 cites W1233997596 @default.
- W1586501510 cites W1479736082 @default.
- W1586501510 cites W1484094963 @default.
- W1586501510 cites W1488423107 @default.
- W1586501510 cites W1490646520 @default.
- W1586501510 cites W1496017988 @default.
- W1586501510 cites W1499109786 @default.
- W1586501510 cites W1524475817 @default.
- W1586501510 cites W1525734429 @default.
- W1586501510 cites W1548084460 @default.
- W1586501510 cites W1561175433 @default.
- W1586501510 cites W1567217875 @default.
- W1586501510 cites W1571919210 @default.
- W1586501510 cites W1572640432 @default.
- W1586501510 cites W1597663953 @default.
- W1586501510 cites W1642243794 @default.
- W1586501510 cites W1677457722 @default.
- W1586501510 cites W1854589240 @default.
- W1586501510 cites W1881079438 @default.
- W1586501510 cites W1903683922 @default.
- W1586501510 cites W1936721474 @default.
- W1586501510 cites W1938984736 @default.
- W1586501510 cites W1966529319 @default.
- W1586501510 cites W1966732663 @default.
- W1586501510 cites W1968139369 @default.
- W1586501510 cites W1968929045 @default.
- W1586501510 cites W1970571759 @default.
- W1586501510 cites W1971427611 @default.
- W1586501510 cites W1972334605 @default.
- W1586501510 cites W1972404682 @default.
- W1586501510 cites W1973484211 @default.
- W1586501510 cites W1974448056 @default.
- W1586501510 cites W1976921465 @default.
- W1586501510 cites W1979586234 @default.
- W1586501510 cites W1982121383 @default.
- W1586501510 cites W1984878190 @default.
- W1586501510 cites W1984967137 @default.
- W1586501510 cites W1985462906 @default.
- W1586501510 cites W1987048771 @default.
- W1586501510 cites W1987388768 @default.
- W1586501510 cites W1991961757 @default.
- W1586501510 cites W1992557615 @default.
- W1586501510 cites W1992763171 @default.
- W1586501510 cites W1993056927 @default.
- W1586501510 cites W1994490974 @default.
- W1586501510 cites W1994962805 @default.
- W1586501510 cites W1995757732 @default.
- W1586501510 cites W1997087774 @default.
- W1586501510 cites W1997814123 @default.
- W1586501510 cites W1998604466 @default.
- W1586501510 cites W1999937407 @default.
- W1586501510 cites W2000007398 @default.
- W1586501510 cites W2001065634 @default.
- W1586501510 cites W2004921550 @default.
- W1586501510 cites W2006107516 @default.
- W1586501510 cites W2006863844 @default.
- W1586501510 cites W2007586038 @default.
- W1586501510 cites W2007660746 @default.
- W1586501510 cites W2009575166 @default.
- W1586501510 cites W2011557758 @default.
- W1586501510 cites W2011756230 @default.
- W1586501510 cites W2012207475 @default.
- W1586501510 cites W2012222895 @default.
- W1586501510 cites W2013591946 @default.
- W1586501510 cites W2014789681 @default.
- W1586501510 cites W2014896785 @default.
- W1586501510 cites W2015418369 @default.
- W1586501510 cites W2016196969 @default.
- W1586501510 cites W2016968207 @default.
- W1586501510 cites W2022959185 @default.
- W1586501510 cites W2025444657 @default.
- W1586501510 cites W2029815010 @default.
- W1586501510 cites W2029858358 @default.
- W1586501510 cites W2030140160 @default.
- W1586501510 cites W2030580169 @default.
- W1586501510 cites W2032295238 @default.
- W1586501510 cites W2032419047 @default.
- W1586501510 cites W2032968624 @default.
- W1586501510 cites W2033087539 @default.
- W1586501510 cites W2034466289 @default.
- W1586501510 cites W2036886561 @default.
- W1586501510 cites W2036940384 @default.
- W1586501510 cites W2038333370 @default.
- W1586501510 cites W2044031364 @default.
- W1586501510 cites W2048088781 @default.
- W1586501510 cites W2048108096 @default.
- W1586501510 cites W2053083724 @default.
- W1586501510 cites W2053912448 @default.
- W1586501510 cites W2053947462 @default.
- W1586501510 cites W2054813108 @default.
- W1586501510 cites W2056220715 @default.