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• W1586569063 endingPage "520" @default.
• W1586569063 startingPage "503" @default.
• W1586569063 abstract "Abnormal intracellular aggregation of tau protein is a pathological condition leading to neuronal death in Alzheimer's disease. Fibrillar and nonfibrillar aggregates of tau protein alter the normal functioning of neurons by disturbing important cellular processes and distinct membranous organelles. However, tau-caused alterations in the nuclear compartment are not totally established so far. In our study we evaluated whether tau protein and its Asp421-truncated variant produce alterations in the normal architecture of the nucleus when expressed in cultured neuroblastoma cells. After 48 hours of transfection, significant deformity of the nuclear compartment with extensive lobulations along the nuclear envelope was observed in SH-SY5Y cells expressing either full-length tau or Asp421-truncated tau. This aberrant formation did not involve either nuclear fragmentation or cell death. The lobulated nuclei were devoid of tau protein, which mostly remained in the cytoplasm in a nonfibrillar state. Degradation of nuclear Lamins was not observed in tau-expressing SH-SY5Y cells, and a cell-cycle analysis did not show aberrant chromosome accumulation. Thus multiple division defects leading to multinucleation were discarded. The lobulated nuclei in tau-expressing SH-SY5Y cells seem to more resemble the multilobular phenotype of the nuclear envelope seen in Lamin-mutated cells from those pathological conditions leading to premature aging. Nevertheless, in our tau-expressing cells, the abnormal formation of cortical and perinuclear rings of tubulin generated by tau binding may be a more feasible mechanism of a nuclear-cytoskeleton generating force that causes the nuclear deformation." @default.
• W1586569063 created "2016-06-24" @default.
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• W1586569063 creator A5079838423 @default.
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• W1586569063 date "2013-07-09" @default.
• W1586569063 modified "2023-10-18" @default.
• W1586569063 title "Alterations in the Nuclear Architecture Produced by the Overexpression of Tau Protein in Neuroblastoma Cells" @default.
• W1586569063 cites W1511517753 @default.
• W1586569063 cites W1529133753 @default.
• W1586569063 cites W1586035563 @default.
• W1586569063 cites W1629179716 @default.
• W1586569063 cites W1675881254 @default.
• W1586569063 cites W1963635405 @default.
• W1586569063 cites W1965769300 @default.
• W1586569063 cites W1969076369 @default.
• W1586569063 cites W1969933454 @default.
• W1586569063 cites W1970320169 @default.
• W1586569063 cites W1970747796 @default.
• W1586569063 cites W1975321314 @default.
• W1586569063 cites W1984442846 @default.
• W1586569063 cites W1985351513 @default.
• W1586569063 cites W1987469323 @default.
• W1586569063 cites W1989215255 @default.
• W1586569063 cites W1994030229 @default.
• W1586569063 cites W2000437020 @default.
• W1586569063 cites W2005108360 @default.
• W1586569063 cites W2005387391 @default.
• W1586569063 cites W2009197621 @default.
• W1586569063 cites W2009784030 @default.
• W1586569063 cites W2011246846 @default.
• W1586569063 cites W2015860144 @default.
• W1586569063 cites W2018632781 @default.
• W1586569063 cites W2021753155 @default.
• W1586569063 cites W2022060333 @default.
• W1586569063 cites W2023283007 @default.
• W1586569063 cites W2025765615 @default.
• W1586569063 cites W2025793462 @default.
• W1586569063 cites W2026823930 @default.
• W1586569063 cites W2032856835 @default.
• W1586569063 cites W2032879521 @default.
• W1586569063 cites W2033318695 @default.
• W1586569063 cites W2033544342 @default.
• W1586569063 cites W2033641488 @default.
• W1586569063 cites W2034219220 @default.
• W1586569063 cites W2035282018 @default.
• W1586569063 cites W2036489475 @default.
• W1586569063 cites W2036755018 @default.
• W1586569063 cites W2042487912 @default.
• W1586569063 cites W2052742260 @default.
• W1586569063 cites W2061739245 @default.
• W1586569063 cites W2066025113 @default.
• W1586569063 cites W2066898830 @default.
• W1586569063 cites W2068011527 @default.
• W1586569063 cites W2079493663 @default.
• W1586569063 cites W2085199754 @default.
• W1586569063 cites W2086729582 @default.
• W1586569063 cites W2088075448 @default.
• W1586569063 cites W2090636859 @default.
• W1586569063 cites W2096317307 @default.
• W1586569063 cites W2105579656 @default.
• W1586569063 cites W2112757893 @default.
• W1586569063 cites W2115754063 @default.
• W1586569063 cites W2117188265 @default.
• W1586569063 cites W2117526022 @default.
• W1586569063 cites W2121050713 @default.
• W1586569063 cites W2125172225 @default.
• W1586569063 cites W2126024001 @default.
• W1586569063 cites W2127708563 @default.
• W1586569063 cites W2132917470 @default.
• W1586569063 cites W2141365953 @default.
• W1586569063 cites W2142939796 @default.
• W1586569063 cites W2143331187 @default.
• W1586569063 cites W2143348288 @default.
• W1586569063 cites W2145488605 @default.
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• W1586569063 cites W2167500696 @default.
• W1586569063 cites W2170926992 @default.
• W1586569063 cites W2182661714 @default.
• W1586569063 cites W2410857930 @default.
• W1586569063 cites W4511481 @default.
• W1586569063 cites W4655498 @default.
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• W1586569063 doi "https://doi.org/10.3233/jad-122401" @default.
• W1586569063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23635409" @default.
• W1586569063 hasPublicationYear "2013" @default.
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