Matches in SemOpenAlex for { <https://semopenalex.org/work/W1586604765> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1586604765 endingPage "1372" @default.
- W1586604765 startingPage "1369" @default.
- W1586604765 abstract "AIM: To study the expression profiles of HBsAg, HBcAg,p21WAF1/CIP1 (p21), Rb genes in hepatocellular carcinoma (HCC) and to investigate their roles in the hepatocarcinogenesis.METHODS: HCC tissue microarray containing 120-min tissues of 40 HCC cases was constructed. HBsAg, HBc Ag,p21 and Rb proteins were immunohistochemically stained by streptavidin-peroxidase conjugated method (S-P). The expression loss of these genes in cancerous, paracancerous tissues and adjacent normal liver tissues of 40HCCs were comparatively examined.RESULTS: The positive rate of HBsAg expression in cancerous tissues of 40 HCCs was 7.5%, which was lower than that in para-cancerous and adjacent normal liver tissues (x2 =12.774, P＜0.01; x2= 18.442, P＜0.01). The positive rate of HBcAg expression in cancerous tissues of 40 HCCs was 20.0%, which was also lower than that in para-cancerous and adjacent normal liver tissues(x2= 9.482, P＜0.01; x2= 14.645, P＜0.01). p21 protein deletion rate in cancerous tissues of 40 HCCs was 27.5%,which was higher than that in para-cancerous and adjacent normal liver tissues (x2 = 7.439, P＜0.01; x2 = 11.174,P＜0.01). p21 protein deletion correlated remarkably with the pathological grade of HCC (x2 = 0.072, P＜0.05). Rb protein deletion rate in cancerous tissues of 40 HCCs was42.5%, which was also higher than that in para-cancerous and adjacent normal liver tissues (x2 = 10.551, P＜0.01;x2= 18.353, P＜0.01). Rb protein deletion rate did not correlate remarkably with tumor size or pathological grade of HCC (x2 = 0.014, P＞0.05; x2 = 0.017, P＞0.05).CONCLUSION: Expression deletion of HBsAg, HBcAg, p21and Rb proteins in HCCs may play important roles in the carcinogenesis of HCC. Tissue microarray is an effective high-throughput technique platform for cancer research." @default.
- W1586604765 created "2016-06-24" @default.
- W1586604765 creator A5000961209 @default.
- W1586604765 creator A5012253993 @default.
- W1586604765 creator A5013835474 @default.
- W1586604765 creator A5024438148 @default.
- W1586604765 creator A5044317284 @default.
- W1586604765 creator A5057263630 @default.
- W1586604765 creator A5079121515 @default.
- W1586604765 date "2005-01-01" @default.
- W1586604765 modified "2023-09-26" @default.
- W1586604765 title "Tissue microarray for high-throughput analysis of gene expression profiles in hepatocellular carcinoma" @default.
- W1586604765 hasPublicationYear "2005" @default.
- W1586604765 type Work @default.
- W1586604765 sameAs 1586604765 @default.
- W1586604765 citedByCount "0" @default.
- W1586604765 crossrefType "journal-article" @default.
- W1586604765 hasAuthorship W1586604765A5000961209 @default.
- W1586604765 hasAuthorship W1586604765A5012253993 @default.
- W1586604765 hasAuthorship W1586604765A5013835474 @default.
- W1586604765 hasAuthorship W1586604765A5024438148 @default.
- W1586604765 hasAuthorship W1586604765A5044317284 @default.
- W1586604765 hasAuthorship W1586604765A5057263630 @default.
- W1586604765 hasAuthorship W1586604765A5079121515 @default.
- W1586604765 hasConcept C104317684 @default.
- W1586604765 hasConcept C142724271 @default.
- W1586604765 hasConcept C150194340 @default.
- W1586604765 hasConcept C153911025 @default.
- W1586604765 hasConcept C193270364 @default.
- W1586604765 hasConcept C203014093 @default.
- W1586604765 hasConcept C204232928 @default.
- W1586604765 hasConcept C2522874641 @default.
- W1586604765 hasConcept C2776231280 @default.
- W1586604765 hasConcept C2777410769 @default.
- W1586604765 hasConcept C2777546739 @default.
- W1586604765 hasConcept C2778019345 @default.
- W1586604765 hasConcept C2779314089 @default.
- W1586604765 hasConcept C2779729466 @default.
- W1586604765 hasConcept C2780593183 @default.
- W1586604765 hasConcept C502942594 @default.
- W1586604765 hasConcept C55493867 @default.
- W1586604765 hasConcept C71924100 @default.
- W1586604765 hasConcept C86803240 @default.
- W1586604765 hasConceptScore W1586604765C104317684 @default.
- W1586604765 hasConceptScore W1586604765C142724271 @default.
- W1586604765 hasConceptScore W1586604765C150194340 @default.
- W1586604765 hasConceptScore W1586604765C153911025 @default.
- W1586604765 hasConceptScore W1586604765C193270364 @default.
- W1586604765 hasConceptScore W1586604765C203014093 @default.
- W1586604765 hasConceptScore W1586604765C204232928 @default.
- W1586604765 hasConceptScore W1586604765C2522874641 @default.
- W1586604765 hasConceptScore W1586604765C2776231280 @default.
- W1586604765 hasConceptScore W1586604765C2777410769 @default.
- W1586604765 hasConceptScore W1586604765C2777546739 @default.
- W1586604765 hasConceptScore W1586604765C2778019345 @default.
- W1586604765 hasConceptScore W1586604765C2779314089 @default.
- W1586604765 hasConceptScore W1586604765C2779729466 @default.
- W1586604765 hasConceptScore W1586604765C2780593183 @default.
- W1586604765 hasConceptScore W1586604765C502942594 @default.
- W1586604765 hasConceptScore W1586604765C55493867 @default.
- W1586604765 hasConceptScore W1586604765C71924100 @default.
- W1586604765 hasConceptScore W1586604765C86803240 @default.
- W1586604765 hasIssue "9" @default.
- W1586604765 hasLocation W15866047651 @default.
- W1586604765 hasOpenAccess W1586604765 @default.
- W1586604765 hasPrimaryLocation W15866047651 @default.
- W1586604765 hasRelatedWork W1523107659 @default.
- W1586604765 hasRelatedWork W2017428871 @default.
- W1586604765 hasRelatedWork W2348131323 @default.
- W1586604765 hasRelatedWork W2350895908 @default.
- W1586604765 hasRelatedWork W2353789721 @default.
- W1586604765 hasRelatedWork W2354000080 @default.
- W1586604765 hasRelatedWork W2356131029 @default.
- W1586604765 hasRelatedWork W2358299584 @default.
- W1586604765 hasRelatedWork W2358391576 @default.
- W1586604765 hasRelatedWork W2361748136 @default.
- W1586604765 hasRelatedWork W2364908691 @default.
- W1586604765 hasRelatedWork W2365224344 @default.
- W1586604765 hasRelatedWork W2375297747 @default.
- W1586604765 hasRelatedWork W2375740166 @default.
- W1586604765 hasRelatedWork W2379876655 @default.
- W1586604765 hasRelatedWork W2380516388 @default.
- W1586604765 hasRelatedWork W2389278160 @default.
- W1586604765 hasRelatedWork W2389785246 @default.
- W1586604765 hasRelatedWork W2393126562 @default.
- W1586604765 hasRelatedWork W2442121793 @default.
- W1586604765 hasVolume "11" @default.
- W1586604765 isParatext "false" @default.
- W1586604765 isRetracted "false" @default.
- W1586604765 magId "1586604765" @default.
- W1586604765 workType "article" @default.