FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1586614077> ?p ?o ?g. }

• W1586614077 endingPage "1546" @default.
• W1586614077 startingPage "1539" @default.
• W1586614077 abstract "A phase I dose-escalation study was performed to determine whether isolated hepatic perfusion (IHP) with melphalan (L-PAM) allows exposure of the liver to much higher drug concentrations than clinically achievable after systemic administration and leads to higher tumour concentrations of L-PAM. Twenty-four patients with colorectal cancer confined to the liver were treated with L-PAM dosages escalating from 0.5 to 4.0 mg kg(-1). During all IHP procedures, leakage of perfusate was monitored. Duration of IHP was aimed at 60 min, but was shortened in eight cases as a result of leakage from the isolated circuit. From these, three patients developed WHO grade 3-4 leukopenia and two patients died due to sepsis. A reversible elevation of liver enzymes and bilirubin was seen in the majority of patients. Only one patient was treated with 4.0 mg kg(-1) L-PAM, who died 8 days after IHP as a result of multiple-organ failure. A statistically significant correlation was found between the dose of L-PAM, peak L-PAM concentrations in perfusate (R = 0.86, P< or =0.001), perfusate area under the concentration-time curve (AUC; R = 0.82, P<0.001), tumour tissue concentrations of L-PAM (R = 0.83, P = 0.011) and patient survival (R = 0.52, P = 0.02). The peak L-PAM concentration and AUC of L-PAM in perfusate at dose level 3.0 mg kg(-1) (n = 5) were respectively 35- and 13-fold higher than in the systemic circulation, and respectively 30- and 5-fold higher than reported for high dose oral L-PAM (80-157 mg m(-2)) and autologous bone marrow transplantation. Median survival after IHP (n = 21) was 19 months and the overall response rate was 29% (17 assessable patients; one complete and four partial remissions). Thus, the maximally tolerated dose of L-PAM delivered via IHP is approximately 3.0 mg kg(-1), leading to high L-PAM concentrations at the target side. Because of the complexity of this treatment modality, IHP has at present no place in routine clinical practice." @default.
• W1586614077 created "2016-06-24" @default.
• W1586614077 creator A5012420123 @default.
• W1586614077 creator A5026031837 @default.
• W1586614077 creator A5028075025 @default.
• W1586614077 creator A5029024695 @default.
• W1586614077 creator A5043883422 @default.
• W1586614077 creator A5058922925 @default.
• W1586614077 creator A5062227574 @default.
• W1586614077 creator A5068540938 @default.
• W1586614077 creator A5084775211 @default.
• W1586614077 creator A5089970764 @default.
• W1586614077 creator A5090839352 @default.
• W1586614077 date "2000-01-01" @default.
• W1586614077 modified "2023-10-17" @default.
• W1586614077 title "True" @default.
• W1586614077 cites W1651023829 @default.
• W1586614077 cites W1928190115 @default.
• W1586614077 cites W1970668456 @default.
• W1586614077 cites W1981583705 @default.
• W1586614077 cites W1989604986 @default.
• W1586614077 cites W2015320879 @default.
• W1586614077 cites W2025195895 @default.
• W1586614077 cites W2025507836 @default.
• W1586614077 cites W2029925895 @default.
• W1586614077 cites W2052358254 @default.
• W1586614077 cites W2056472648 @default.
• W1586614077 cites W2057484574 @default.
• W1586614077 cites W2072403754 @default.
• W1586614077 cites W2075532811 @default.
• W1586614077 cites W2106424616 @default.
• W1586614077 cites W2131138289 @default.
• W1586614077 cites W2146382462 @default.
• W1586614077 cites W2161052320 @default.
• W1586614077 cites W2163113365 @default.
• W1586614077 cites W2203518391 @default.
• W1586614077 cites W2221252789 @default.
• W1586614077 doi "https://doi.org/10.1054/bjoc.2000.1175" @default.
• W1586614077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2363396" @default.
• W1586614077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10789721" @default.
• W1586614077 hasPublicationYear "2000" @default.
• W1586614077 type Work @default.
• W1586614077 sameAs 1586614077 @default.
• W1586614077 citedByCount "48" @default.
• W1586614077 countsByYear W15866140772013 @default.
• W1586614077 countsByYear W15866140772014 @default.
• W1586614077 countsByYear W15866140772015 @default.
• W1586614077 countsByYear W15866140772016 @default.
• W1586614077 countsByYear W15866140772018 @default.
• W1586614077 countsByYear W15866140772019 @default.
• W1586614077 countsByYear W15866140772020 @default.
• W1586614077 countsByYear W15866140772021 @default.
• W1586614077 countsByYear W15866140772022 @default.
• W1586614077 countsByYear W15866140772023 @default.
• W1586614077 crossrefType "journal-article" @default.
• W1586614077 hasAuthorship W1586614077A5012420123 @default.
• W1586614077 hasAuthorship W1586614077A5026031837 @default.
• W1586614077 hasAuthorship W1586614077A5028075025 @default.
• W1586614077 hasAuthorship W1586614077A5029024695 @default.
• W1586614077 hasAuthorship W1586614077A5043883422 @default.
• W1586614077 hasAuthorship W1586614077A5058922925 @default.
• W1586614077 hasAuthorship W1586614077A5062227574 @default.
• W1586614077 hasAuthorship W1586614077A5068540938 @default.
• W1586614077 hasAuthorship W1586614077A5084775211 @default.
• W1586614077 hasAuthorship W1586614077A5089970764 @default.
• W1586614077 hasAuthorship W1586614077A5090839352 @default.
• W1586614077 hasBestOaLocation W15866140771 @default.
• W1586614077 hasConcept C126322002 @default.
• W1586614077 hasConcept C126894567 @default.
• W1586614077 hasConcept C146957229 @default.
• W1586614077 hasConcept C162156334 @default.
• W1586614077 hasConcept C2776694085 @default.
• W1586614077 hasConcept C2777513400 @default.
• W1586614077 hasConcept C2778384902 @default.
• W1586614077 hasConcept C2778684742 @default.
• W1586614077 hasConcept C2780873365 @default.
• W1586614077 hasConcept C29730261 @default.
• W1586614077 hasConcept C71924100 @default.
• W1586614077 hasConcept C90924648 @default.
• W1586614077 hasConceptScore W1586614077C126322002 @default.
• W1586614077 hasConceptScore W1586614077C126894567 @default.
• W1586614077 hasConceptScore W1586614077C146957229 @default.
• W1586614077 hasConceptScore W1586614077C162156334 @default.
• W1586614077 hasConceptScore W1586614077C2776694085 @default.
• W1586614077 hasConceptScore W1586614077C2777513400 @default.
• W1586614077 hasConceptScore W1586614077C2778384902 @default.
• W1586614077 hasConceptScore W1586614077C2778684742 @default.
• W1586614077 hasConceptScore W1586614077C2780873365 @default.
• W1586614077 hasConceptScore W1586614077C29730261 @default.
• W1586614077 hasConceptScore W1586614077C71924100 @default.
• W1586614077 hasConceptScore W1586614077C90924648 @default.
• W1586614077 hasIssue "9" @default.
• W1586614077 hasLocation W15866140771 @default.
• W1586614077 hasLocation W15866140772 @default.
• W1586614077 hasLocation W15866140773 @default.
• W1586614077 hasLocation W15866140774 @default.
• W1586614077 hasOpenAccess W1586614077 @default.
• W1586614077 hasPrimaryLocation W15866140771 @default.

• next