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- W1586700545 abstract "Vasculitis is defined as chronic blood vessel inflammation confirmed by histologic evidence. The typical course of the disease may lead to blood vessel stenosis/occlusion causing organ ischemia, or to thinning of the blood vessel which results in aneurysm formation or hemorrhage. Although in 1994 the American College of Rheumatology introduced morphological and histopathological classification criteria for the most common forms of vasculitides at the Chapel Hill Consensus Conference (CHCC) (Jennette et al., 1994), vasculitides are generally divided into two main categories. Primary vasculitides represent the first group, are the entities of unknown cause in which blood vessel inflammation is the pathologic basis of tissue injury. Secondary vasculitides constitute the second, heterogeneous and much bigger group, in which inflammatory process occurs in association with an underlying disease or exposure. The pathophysiology of the vasculitides is based on immunologic mechanisms. These mechanisms appear to play an active role in mediating the inflammatory response, but precise mechanisms still remain poorly understood. Although the primary events that initiate this process remain largely unknown, recent investigations have brought us closer to understanding some of the critical pathways involved in disease and provided a rationale for the study of novel therapeutic agents (Langford, 2010). Intravenous immunoglobulin (IVIG) represents one of the novel alternative choices for the treatment as the standard regimen and IVIG has now become an important option in a number of clinical indications beyond primary immunodeficiency, including vasculitides." @default.
- W1586700545 created "2016-06-24" @default.
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- W1586700545 date "2011-11-09" @default.
- W1586700545 modified "2023-09-30" @default.
- W1586700545 title "Intravenous Immunoglobulin Therapy in Primary Vasculitides" @default.
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- W1586700545 doi "https://doi.org/10.5772/21534" @default.
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