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- W158672208 abstract "Abstract Studies of the capacity of plasma proteins to bind hemoglobin were made in patients with sickle cell anemia (SS), sickle cell trait (SA), hemoglobin C disease and in patients with hemolytic anemias. Hemoglobin binding was quantitatively normal in sickle cell trait, but was greatly reduced or absent in sickle cell anemia, hemoglobin C disease and in other hemolytic disorders. These alterations have been attributed to a reduction in the level of hemoglobin-binding proteins in circulating plasma. The mechanism of this reduction was not established, but the observed changes were correlated with the presence of increased hemolytic activity. The binding of hemoglobin C and hemoglobin S by normal plasma was quantitatively normal." @default.
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- W158672208 date "1959-09-01" @default.
- W158672208 modified "2023-09-27" @default.
- W158672208 title "Plasma Hemoglobin-Binding Capacity in Sickle Cell Disease" @default.
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- W158672208 doi "https://doi.org/10.1182/blood.v14.9.1047.1047" @default.
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