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- W1586783369 abstract "We describe a genetic model for neurodegeneration in the nematode Caenorhabditis elegans . Constitutive activation of the GTP-binding protein Gα s induces neurodegeneration. Neuron loss occurs in two phases whereby affected cells undergo a swelling response in young larvae and subsequently die sometime during larval development. Different neural cell types vary greatly in their susceptibility to Gα s -induced cytotoxicity, ranging from 0 to 88% of cells affected. Mutations that prevent programmed cell death do not prevent Gα s -induced killing, suggesting that these deaths do not occur by apoptosis. Mutations in three genes protect against Gα s -induced cell deaths. The acy-1 gene is absolutely required for neurodegeneration, and the predicted ACY-1 protein is highly similar (40% identical) to mammalian adenylyl cyclases. Thus, G s -induced neurodegeneration is mediated by the second messenger cAMP. Mutations in the unc-36 and eat-4 genes are partially neuroprotective, which indicates that endogenous signaling modulates the severity of the neurotoxic effects of Gα s . These experiments define an intracellular signaling cascade that triggers a necrotic form of neurodegeneration." @default.
- W1586783369 created "2016-06-24" @default.
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- W1586783369 date "1998-04-15" @default.
- W1586783369 modified "2023-09-23" @default.
- W1586783369 title "Gα<sub>s</sub>-Induced Neurodegeneration in<i>Caenorhabditis elegans</i>" @default.
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- W1586783369 cites W1887384647 @default.
- W1586783369 cites W1904905451 @default.
- W1586783369 cites W1942841837 @default.
- W1586783369 cites W1949220541 @default.
- W1586783369 cites W1964817556 @default.
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- W1586783369 cites W1973899245 @default.
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- W1586783369 cites W1976054510 @default.
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- W1586783369 cites W1989952069 @default.
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- W1586783369 doi "https://doi.org/10.1523/jneurosci.18-08-02871.1998" @default.
- W1586783369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6792578" @default.
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