Matches in SemOpenAlex for { <https://semopenalex.org/work/W1586910496> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1586910496 endingPage "744" @default.
- W1586910496 startingPage "737" @default.
- W1586910496 abstract "Aim: Correlation of cytochrome P450 (CYPs) with preneoplastic changes in the early stage of hepatocarcinogenesis is still unclear. To detect the expression of carcinogen-metabolizing related microsomal P450 enzymes, namely the CYP1A1,CYP1A2, CYP2B 1/2, CYP2E1, and CYP3A, we performed the medium-term bioassay of Ito's model in Sprague-Dawley rats. Methods: The amount and activity of CYP were assessed by biochemical and immunohistochemical methods in week 8.The correlation between CYP expression and microsomal oxidative stress was investigated by comparing the generation of microsomal lipid peroxidation in the presence or absence of specific CYP inhibitor. Results: In the DEN-2-AAF and 2-AAF alone groups, the expression of CYP1A1 and CYP2E1 were up-regulated and the expression of CYP2B 1/2 and CYP1 A2 were quite the contrary. Strong staining of CYP2E1 and CYP2BI/2 was found around the centrolobular vein and weak staining in the altered hepatic foci revealed by immunohistochemical procedure.There was no significant change in the activity of CYP3A among the 4 groups.Altered hepatic tissue bore more microsomal NADPH (nicotinamide adenine dimucleotide phosphate,reduced form)-dependent lipid peroxidation than normal tissue. And the difference among the 4 groups disappeared when CYP2E1 was inhibited. More microsomal lipid peroxidation was generated when incubated with CYP1A inhibitor α-naphthoflavone. Conclusion: CYP altered their expression levels and these alterations can play important roles in the alteration of cell redox status of preneoplastic tissue in the early stage of hepatocarcinogenesis." @default.
- W1586910496 created "2016-06-24" @default.
- W1586910496 creator A5029622468 @default.
- W1586910496 creator A5031520435 @default.
- W1586910496 creator A5034827233 @default.
- W1586910496 creator A5041209833 @default.
- W1586910496 creator A5050609033 @default.
- W1586910496 creator A5064698514 @default.
- W1586910496 creator A5072795051 @default.
- W1586910496 creator A5086591531 @default.
- W1586910496 date "2005-01-01" @default.
- W1586910496 modified "2023-09-22" @default.
- W1586910496 title "Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis" @default.
- W1586910496 hasPublicationYear "2005" @default.
- W1586910496 type Work @default.
- W1586910496 sameAs 1586910496 @default.
- W1586910496 citedByCount "0" @default.
- W1586910496 crossrefType "journal-article" @default.
- W1586910496 hasAuthorship W1586910496A5029622468 @default.
- W1586910496 hasAuthorship W1586910496A5031520435 @default.
- W1586910496 hasAuthorship W1586910496A5034827233 @default.
- W1586910496 hasAuthorship W1586910496A5041209833 @default.
- W1586910496 hasAuthorship W1586910496A5050609033 @default.
- W1586910496 hasAuthorship W1586910496A5064698514 @default.
- W1586910496 hasAuthorship W1586910496A5072795051 @default.
- W1586910496 hasAuthorship W1586910496A5086591531 @default.
- W1586910496 hasConcept C114246631 @default.
- W1586910496 hasConcept C11824378 @default.
- W1586910496 hasConcept C119795356 @default.
- W1586910496 hasConcept C126322002 @default.
- W1586910496 hasConcept C134018914 @default.
- W1586910496 hasConcept C140027455 @default.
- W1586910496 hasConcept C181199279 @default.
- W1586910496 hasConcept C185592680 @default.
- W1586910496 hasConcept C203014093 @default.
- W1586910496 hasConcept C204232928 @default.
- W1586910496 hasConcept C2776151105 @default.
- W1586910496 hasConcept C2777989768 @default.
- W1586910496 hasConcept C2780768313 @default.
- W1586910496 hasConcept C2780829032 @default.
- W1586910496 hasConcept C38485361 @default.
- W1586910496 hasConcept C526171541 @default.
- W1586910496 hasConcept C55493867 @default.
- W1586910496 hasConcept C71924100 @default.
- W1586910496 hasConcept C86745063 @default.
- W1586910496 hasConcept C86803240 @default.
- W1586910496 hasConcept C87644729 @default.
- W1586910496 hasConceptScore W1586910496C114246631 @default.
- W1586910496 hasConceptScore W1586910496C11824378 @default.
- W1586910496 hasConceptScore W1586910496C119795356 @default.
- W1586910496 hasConceptScore W1586910496C126322002 @default.
- W1586910496 hasConceptScore W1586910496C134018914 @default.
- W1586910496 hasConceptScore W1586910496C140027455 @default.
- W1586910496 hasConceptScore W1586910496C181199279 @default.
- W1586910496 hasConceptScore W1586910496C185592680 @default.
- W1586910496 hasConceptScore W1586910496C203014093 @default.
- W1586910496 hasConceptScore W1586910496C204232928 @default.
- W1586910496 hasConceptScore W1586910496C2776151105 @default.
- W1586910496 hasConceptScore W1586910496C2777989768 @default.
- W1586910496 hasConceptScore W1586910496C2780768313 @default.
- W1586910496 hasConceptScore W1586910496C2780829032 @default.
- W1586910496 hasConceptScore W1586910496C38485361 @default.
- W1586910496 hasConceptScore W1586910496C526171541 @default.
- W1586910496 hasConceptScore W1586910496C55493867 @default.
- W1586910496 hasConceptScore W1586910496C71924100 @default.
- W1586910496 hasConceptScore W1586910496C86745063 @default.
- W1586910496 hasConceptScore W1586910496C86803240 @default.
- W1586910496 hasConceptScore W1586910496C87644729 @default.
- W1586910496 hasIssue "6" @default.
- W1586910496 hasLocation W15869104961 @default.
- W1586910496 hasOpenAccess W1586910496 @default.
- W1586910496 hasPrimaryLocation W15869104961 @default.
- W1586910496 hasRelatedWork W1578911536 @default.
- W1586910496 hasRelatedWork W1983773316 @default.
- W1586910496 hasRelatedWork W1999855246 @default.
- W1586910496 hasRelatedWork W2048881874 @default.
- W1586910496 hasRelatedWork W2073660754 @default.
- W1586910496 hasRelatedWork W2077574170 @default.
- W1586910496 hasRelatedWork W2084566862 @default.
- W1586910496 hasRelatedWork W2098153346 @default.
- W1586910496 hasRelatedWork W2099901508 @default.
- W1586910496 hasRelatedWork W2140725636 @default.
- W1586910496 hasRelatedWork W2141766357 @default.
- W1586910496 hasRelatedWork W2145361996 @default.
- W1586910496 hasRelatedWork W2147652734 @default.
- W1586910496 hasRelatedWork W22085617 @default.
- W1586910496 hasRelatedWork W2257378276 @default.
- W1586910496 hasRelatedWork W2305015145 @default.
- W1586910496 hasRelatedWork W2495924608 @default.
- W1586910496 hasRelatedWork W2622928399 @default.
- W1586910496 hasRelatedWork W2913199838 @default.
- W1586910496 hasRelatedWork W2739292277 @default.
- W1586910496 hasVolume "26" @default.
- W1586910496 isParatext "false" @default.
- W1586910496 isRetracted "false" @default.
- W1586910496 magId "1586910496" @default.
- W1586910496 workType "article" @default.