FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1586918204> ?p ?o ?g. }

• W1586918204 endingPage "59" @default.
• W1586918204 startingPage "53" @default.
• W1586918204 abstract "The diagnosis of Alzheimer's disease (AD) relies principally on clinical criteria for probable and possible AD as defined by the NINCDS-ADRDRA. The field is desperately lacking of biological markers to assist with AD diagnosis and verification of treatment efficacy. According to the Consensus Report of the Working Group on Molecular and Biochemical Markers of Alzheimer's Disease, in order to qualify as a biomarker the sample in question must adhere to certain basic requirements, including the ability to: reflect AD pathology and differentiate it from other dementia with an 80% sensitivity; be reliable and reproducible; be easy to perform and analyze; remain relatively inexpensive. Beta secretases are crucial enzymes in the pathogenesis of AD. Given its primary role in brain amyloidogenesis and its ubiquitous expression, one may consider measuring peripheral BACE1 levels and activity as biomarkers of AD, like performed in the brain and cerebrospinal fluid. However, very little is known about the periphery and whether peripheral BACE1 is involved in AD pathogenesis or mirrors AD progression. Moreover, no investigation has focused on the possibility of monitoring peripheral BACE1 to assess the efficiency of BACE1 inhibitors during the course of clinical trials. Part of the problem may be attributed to the lack of sensitive molecular tools which are absolutely necessary to use BACE1 as a biomarker. In this review we evaluate the progress and feasibility of developing BACE1 as a biomarker for AD in different tissues." @default.
• W1586918204 created "2016-06-24" @default.
• W1586918204 creator A5012941668 @default.
• W1586918204 creator A5088718520 @default.
• W1586918204 date "2011-04-22" @default.
• W1586918204 modified "2023-09-26" @default.
• W1586918204 title "BACE1 as a Potential Biomarker for Alzheimer's Disease" @default.
• W1586918204 cites W1536258113 @default.
• W1586918204 cites W1551503109 @default.
• W1586918204 cites W1596984737 @default.
• W1586918204 cites W1644122431 @default.
• W1586918204 cites W1796916475 @default.
• W1586918204 cites W1964869332 @default.
• W1586918204 cites W1971678374 @default.
• W1586918204 cites W1972012989 @default.
• W1586918204 cites W1972025839 @default.
• W1586918204 cites W1985747467 @default.
• W1586918204 cites W1986400971 @default.
• W1586918204 cites W1989453114 @default.
• W1586918204 cites W1996560271 @default.
• W1586918204 cites W1996799369 @default.
• W1586918204 cites W2000536660 @default.
• W1586918204 cites W2001032146 @default.
• W1586918204 cites W2001477615 @default.
• W1586918204 cites W2018435435 @default.
• W1586918204 cites W2023274935 @default.
• W1586918204 cites W2024369731 @default.
• W1586918204 cites W2036963269 @default.
• W1586918204 cites W2038965421 @default.
• W1586918204 cites W2045572065 @default.
• W1586918204 cites W2046248903 @default.
• W1586918204 cites W2047418563 @default.
• W1586918204 cites W2050599285 @default.
• W1586918204 cites W2062283435 @default.
• W1586918204 cites W2063978545 @default.
• W1586918204 cites W2074859138 @default.
• W1586918204 cites W2075295221 @default.
• W1586918204 cites W2076868543 @default.
• W1586918204 cites W2077756886 @default.
• W1586918204 cites W2077966741 @default.
• W1586918204 cites W2079402113 @default.
• W1586918204 cites W2082938119 @default.
• W1586918204 cites W2093426751 @default.
• W1586918204 cites W2094777896 @default.
• W1586918204 cites W2095367777 @default.
• W1586918204 cites W2096045337 @default.
• W1586918204 cites W2096277075 @default.
• W1586918204 cites W2104189790 @default.
• W1586918204 cites W2122981189 @default.
• W1586918204 cites W2129771097 @default.
• W1586918204 cites W2131795348 @default.
• W1586918204 cites W2133019124 @default.
• W1586918204 cites W2135624681 @default.
• W1586918204 cites W2147177629 @default.
• W1586918204 cites W2159223294 @default.
• W1586918204 cites W2162815565 @default.
• W1586918204 cites W2165503155 @default.
• W1586918204 cites W2166796314 @default.
• W1586918204 cites W2167551295 @default.
• W1586918204 cites W234476372 @default.
• W1586918204 cites W2422339853 @default.
• W1586918204 doi "https://doi.org/10.3233/jad-2011-110017" @default.
• W1586918204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3313825" @default.
• W1586918204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21403391" @default.
• W1586918204 hasPublicationYear "2011" @default.
• W1586918204 type Work @default.
• W1586918204 sameAs 1586918204 @default.
• W1586918204 citedByCount "49" @default.
• W1586918204 countsByYear W15869182042012 @default.
• W1586918204 countsByYear W15869182042013 @default.
• W1586918204 countsByYear W15869182042014 @default.
• W1586918204 countsByYear W15869182042015 @default.
• W1586918204 countsByYear W15869182042016 @default.
• W1586918204 countsByYear W15869182042017 @default.
• W1586918204 countsByYear W15869182042018 @default.
• W1586918204 countsByYear W15869182042019 @default.
• W1586918204 countsByYear W15869182042020 @default.
• W1586918204 countsByYear W15869182042021 @default.
• W1586918204 countsByYear W15869182042022 @default.
• W1586918204 countsByYear W15869182042023 @default.
• W1586918204 crossrefType "journal-article" @default.
• W1586918204 hasAuthorship W1586918204A5012941668 @default.
• W1586918204 hasAuthorship W1586918204A5088718520 @default.
• W1586918204 hasBestOaLocation W15869182042 @default.
• W1586918204 hasConcept C142724271 @default.
• W1586918204 hasConcept C15744967 @default.
• W1586918204 hasConcept C169760540 @default.
• W1586918204 hasConcept C2779134260 @default.
• W1586918204 hasConcept C2779483572 @default.
• W1586918204 hasConcept C2780942790 @default.
• W1586918204 hasConcept C2781197716 @default.
• W1586918204 hasConcept C502032728 @default.
• W1586918204 hasConcept C535046627 @default.
• W1586918204 hasConcept C55493867 @default.
• W1586918204 hasConcept C60644358 @default.
• W1586918204 hasConcept C71924100 @default.
• W1586918204 hasConcept C86803240 @default.
• W1586918204 hasConceptScore W1586918204C142724271 @default.

• next