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• W1586927377 abstract "Modern chemotherapy and supportive care have resulted in long-term event-free survival in >80% of children with acute lymphoblastic leukemia (ALL) (1–3). However, therapy remains intensive, toxic, and sometimes lethal. To improve outcome for patients in the future, therapy will need to be more patient- and leukemia-specific and less toxic. Although nearly all investigators agree on this goal, there are a variety of opinions regarding how best to optimize treatment for children with ALL. In the preceding chapter (Chapter 5), Drs. Schrappe and Stanulla identified six specific areas of controversy: (1) the clinical and laboratory features that determine treatment choice, including early response to therapy; (2) the relevance of minimal residual disease measurements; (3) the intensity of initial remission induction therapy; (4) optimal central nervous system (CNS) therapy in terms of relative efficacy and toxicity; (5) optimal duration of therapy; and (6) the indications for stem cell transplantation during first complete remission. Because we are in agreement with most of the views expressed by Drs. Schrappe and Stanulla, we will focus on those areas in which there are alternative points of view." @default.
• W1586927377 created "2016-06-24" @default.
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• W1586927377 date "2003-01-01" @default.
• W1586927377 modified "2023-09-23" @default.
• W1586927377 title "Treatment of Childhood Acute Lymphoblastic Leukemia" @default.
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• W1586927377 doi "https://doi.org/10.1007/978-1-59259-307-1_6" @default.
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