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- W158749304 abstract "We have developed a new injectable biomaterial composed of gelatinized capillary-alginate hydrogel. This degradable gel, termed CapGel-GT, forms a unique microstructure of parallel capillary-like channels. The diameter and density of the channels can be adjusted to facilitate cell, tissue and blood vessel ingrowth (Fig. 1A). Accordingly, via a 28G needle CapGel-GT was injected into the antero-septal left ventricular (LV) wall of normal rats (n=14) and the infarct border zone following permanent LAD ligation in rats with MI (n=65). LV function was assessed (echo) 48hrs following MI (week 0), at 4 weeks, and at 8 weeks. Control animals received no treatment following MI. CapGel-GT injection was not associated with increased mortality. Fractional shortening (FS) for rats receiving CapGel-GT was significantly higher at both week 4 and 8 echo assessments compared to week 0 as well as compared to FS of the control group animals at week 4 and 8 (Fig. 1F). Fractional area change was also significantly higher in t..." @default.
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- W158749304 date "2012-11-20" @default.
- W158749304 modified "2023-09-24" @default.
- W158749304 title "Abstract 17004: Intramyocardial Injection of Gelatinized Capillary-Alginate Hydrogel Enhances Recovery of LV Function Post-MI" @default.
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