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• W1587524277 abstract "Somatic mutations in the mitochondrial genome occur in numerous tumor types including brain tumors. These mutations are generally found in the hypervariable regions I and II of the displacement loop and unlikely alter mitochondrial function. Two hypervariable regions of mononucleotide repeats occur in the mouse mitochondrial genome, i.e., the origin of replication of the light strand (OL) and the Arg tRNA.In this study we examined the entire mitochondrial genome in a series of chemically induced brain tumors in the C57BL/6J strain and spontaneous brain tumors in the VM mouse strain. The tumor mtDNA was compared to that of mtDNA in brain mitochondrial populations from the corresponding syngeneic mouse host strain.Direct sequencing revealed a few homoplasmic base pair insertions, deletions, and substitutions in the tumor cells mainly in regions of mononucleotide repeats. A heteroplasmic mutation in the 16srRNA gene was detected in a spontaneous metastatic VM brain tumor.None of the mutations were considered pathogenic, indicating that mtDNA somatic mutations do not likely contribute to the initiation or progression of these diverse mouse brain tumors." @default.
• W1587524277 created "2016-06-24" @default.
• W1587524277 creator A5008685777 @default.
• W1587524277 creator A5021162065 @default.
• W1587524277 date "2005-08-16" @default.
• W1587524277 modified "2023-09-24" @default.
• W1587524277 title "Absence of pathogenic mitochondrial DNA mutations in mouse brain tumors" @default.
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• W1587524277 doi "https://doi.org/10.1186/1471-2407-5-102" @default.
• W1587524277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1199588" @default.
• W1587524277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16105171" @default.
• W1587524277 hasPublicationYear "2005" @default.
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