FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1587636616> ?p ?o ?g. }

• W1587636616 abstract "Important thermodynamic parameters including denaturant equilibrium m values (m(eq)) and heat capacity changes (ΔCp) can be predicted based on changes in Solvent Accessible Surface Area (SASA) upon unfolding. Crosslinks such as disulfide bonds influence the stability of the proteins by decreasing the entropy gain as well as reduction of SASA of unfolded state. The aim of the study was to develop mathematical models to predict the effect of crosslinks on ΔSASA and ultimately on m(eq) and ΔCp based on in silico methods. Changes of SASA upon computationally simulated unfolding were calculated for a set of 45 proteins with known m(eq) and ΔCp values and the effect of crosslinks on ΔSASA of unfolding was investigated. The results were used to predict the m(eq) of denaturation for guanidine hydrochloride and urea, as well as ΔCp for the studied proteins with overall error of 20%, 31% and 17%, respectively. The results of the current study were in close agreement with those obtained from the previous studies." @default.
• W1587636616 created "2016-06-24" @default.
• W1587636616 creator A5000390912 @default.
• W1587636616 creator A5012200713 @default.
• W1587636616 creator A5033164477 @default.
• W1587636616 creator A5040891071 @default.
• W1587636616 date "2012-01-01" @default.
• W1587636616 modified "2023-09-26" @default.
• W1587636616 title "In silico Evaluation of Crosslinking Effects on Denaturant m(eq) values and ΔCp upon Protein Unfolding." @default.
• W1587636616 cites W1544040231 @default.
• W1587636616 cites W1548230107 @default.
• W1587636616 cites W1571010957 @default.
• W1587636616 cites W1583149693 @default.
• W1587636616 cites W1971489207 @default.
• W1587636616 cites W2008708467 @default.
• W1587636616 cites W2014842950 @default.
• W1587636616 cites W2015642465 @default.
• W1587636616 cites W2024999430 @default.
• W1587636616 cites W2030753212 @default.
• W1587636616 cites W2044791372 @default.
• W1587636616 cites W2054448211 @default.
• W1587636616 cites W2060002111 @default.
• W1587636616 cites W2062346723 @default.
• W1587636616 cites W2084135361 @default.
• W1587636616 cites W2097647470 @default.
• W1587636616 cites W2106845528 @default.
• W1587636616 cites W2117747873 @default.
• W1587636616 cites W2123705273 @default.
• W1587636616 cites W2130303726 @default.
• W1587636616 cites W2130479394 @default.
• W1587636616 cites W2162166182 @default.
• W1587636616 cites W2171268876 @default.
• W1587636616 cites W632523938 @default.
• W1587636616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3558204" @default.
• W1587636616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23408172" @default.
• W1587636616 hasPublicationYear "2012" @default.
• W1587636616 type Work @default.
• W1587636616 sameAs 1587636616 @default.
• W1587636616 citedByCount "0" @default.
• W1587636616 crossrefType "journal-article" @default.
• W1587636616 hasAuthorship W1587636616A5000390912 @default.
• W1587636616 hasAuthorship W1587636616A5012200713 @default.
• W1587636616 hasAuthorship W1587636616A5033164477 @default.
• W1587636616 hasAuthorship W1587636616A5040891071 @default.
• W1587636616 hasConcept C104317684 @default.
• W1587636616 hasConcept C11072593 @default.
• W1587636616 hasConcept C121332964 @default.
• W1587636616 hasConcept C13965031 @default.
• W1587636616 hasConcept C147597530 @default.
• W1587636616 hasConcept C151730666 @default.
• W1587636616 hasConcept C185592680 @default.
• W1587636616 hasConcept C2775905019 @default.
• W1587636616 hasConcept C2776335000 @default.
• W1587636616 hasConcept C2776460385 @default.
• W1587636616 hasConcept C2776923230 @default.
• W1587636616 hasConcept C2779463914 @default.
• W1587636616 hasConcept C2988375501 @default.
• W1587636616 hasConcept C55493867 @default.
• W1587636616 hasConcept C86803240 @default.
• W1587636616 hasConcept C97355855 @default.
• W1587636616 hasConceptScore W1587636616C104317684 @default.
• W1587636616 hasConceptScore W1587636616C11072593 @default.
• W1587636616 hasConceptScore W1587636616C121332964 @default.
• W1587636616 hasConceptScore W1587636616C13965031 @default.
• W1587636616 hasConceptScore W1587636616C147597530 @default.
• W1587636616 hasConceptScore W1587636616C151730666 @default.
• W1587636616 hasConceptScore W1587636616C185592680 @default.
• W1587636616 hasConceptScore W1587636616C2775905019 @default.
• W1587636616 hasConceptScore W1587636616C2776335000 @default.
• W1587636616 hasConceptScore W1587636616C2776460385 @default.
• W1587636616 hasConceptScore W1587636616C2776923230 @default.
• W1587636616 hasConceptScore W1587636616C2779463914 @default.
• W1587636616 hasConceptScore W1587636616C2988375501 @default.
• W1587636616 hasConceptScore W1587636616C55493867 @default.
• W1587636616 hasConceptScore W1587636616C86803240 @default.
• W1587636616 hasConceptScore W1587636616C97355855 @default.
• W1587636616 hasLocation W15876366161 @default.
• W1587636616 hasOpenAccess W1587636616 @default.
• W1587636616 hasPrimaryLocation W15876366161 @default.
• W1587636616 hasRelatedWork W1505935267 @default.
• W1587636616 hasRelatedWork W1569015250 @default.
• W1587636616 hasRelatedWork W1586605199 @default.
• W1587636616 hasRelatedWork W1975064838 @default.
• W1587636616 hasRelatedWork W1981583379 @default.
• W1587636616 hasRelatedWork W2001458612 @default.
• W1587636616 hasRelatedWork W2017076970 @default.
• W1587636616 hasRelatedWork W2029111746 @default.
• W1587636616 hasRelatedWork W2029712458 @default.
• W1587636616 hasRelatedWork W2033222739 @default.
• W1587636616 hasRelatedWork W2051076992 @default.
• W1587636616 hasRelatedWork W2053611657 @default.
• W1587636616 hasRelatedWork W2057573078 @default.
• W1587636616 hasRelatedWork W2060478793 @default.
• W1587636616 hasRelatedWork W2076828221 @default.
• W1587636616 hasRelatedWork W2081166552 @default.
• W1587636616 hasRelatedWork W2329618097 @default.
• W1587636616 hasRelatedWork W2962691718 @default.
• W1587636616 hasRelatedWork W3023782854 @default.
• W1587636616 hasRelatedWork W3046011345 @default.
• W1587636616 isParatext "false" @default.

• next