Matches in SemOpenAlex for { <https://semopenalex.org/work/W1587763824> ?p ?o ?g. }
- W1587763824 endingPage "21967" @default.
- W1587763824 startingPage "21962" @default.
- W1587763824 abstract "We have previously reported that apolipoprotein (a) is a substrate for transglutaminases. We now demonstrate that plasminogen which is homologous to apolipoprotein (a), is also modified by these enzymes. Transglutaminases from different sources mediated the incorporation of monodansyl-cadaverine into plasminogen, indicating the presence of reactive glutamine(s) in plasminogen. Reactive lysines were also identified using the lysine-decorating peptide dansyl-PGGQQIV. In addition, transglutaminases catalyzed the formation of plasminogen homopolymers and plasminogen-fibronectin heteropolymers. Human umbilical vein endothelial cells cross-linked plasminogen into high molecular mass aggregates. Cross-linked plasminogen was cell associated, and no cross-linking of plasminogen was seen in the fluid-phase. Large molecular mass plasminogen generated on the human umbilical vein endothelial cell (HUVEC) surface could not be eluted with epsilon-aminocapoic acid and was activatable by tissue plasminogen activator. These results suggest that, following non-covalent association of plasminogen with the HUVEC surface, cell surface-associated transglutaminase catalyzes cross-linking of plasminogen into large molecular mass aggregates that can be converted into functional plasmin. It is proposed that transglutaminases may function to localize plasminogen to cell surfaces and matrices of tissues." @default.
- W1587763824 created "2016-06-24" @default.
- W1587763824 creator A5010489983 @default.
- W1587763824 creator A5076950957 @default.
- W1587763824 creator A5086391681 @default.
- W1587763824 date "1993-10-01" @default.
- W1587763824 modified "2023-10-09" @default.
- W1587763824 title "Transglutaminases catalyze cross-linking of plasminogen to fibronectin and human endothelial cells." @default.
- W1587763824 cites W109964576 @default.
- W1587763824 cites W1481390215 @default.
- W1587763824 cites W1488060793 @default.
- W1587763824 cites W1493130196 @default.
- W1587763824 cites W1498670072 @default.
- W1587763824 cites W1504879193 @default.
- W1587763824 cites W1508378505 @default.
- W1587763824 cites W1514181378 @default.
- W1587763824 cites W1521555848 @default.
- W1587763824 cites W1530430498 @default.
- W1587763824 cites W1550507433 @default.
- W1587763824 cites W1553444768 @default.
- W1587763824 cites W1559877912 @default.
- W1587763824 cites W1560399205 @default.
- W1587763824 cites W1561276659 @default.
- W1587763824 cites W1680438956 @default.
- W1587763824 cites W1892184508 @default.
- W1587763824 cites W1969537125 @default.
- W1587763824 cites W1979866913 @default.
- W1587763824 cites W1993729215 @default.
- W1587763824 cites W2010933740 @default.
- W1587763824 cites W2015311282 @default.
- W1587763824 cites W2031510621 @default.
- W1587763824 cites W2036170644 @default.
- W1587763824 cites W2046913628 @default.
- W1587763824 cites W2052356760 @default.
- W1587763824 cites W2054050090 @default.
- W1587763824 cites W2054503792 @default.
- W1587763824 cites W2060884414 @default.
- W1587763824 cites W2062005186 @default.
- W1587763824 cites W2071756117 @default.
- W1587763824 cites W2083860201 @default.
- W1587763824 cites W2087316197 @default.
- W1587763824 cites W2088927685 @default.
- W1587763824 cites W2089751418 @default.
- W1587763824 cites W2091998704 @default.
- W1587763824 cites W2092004637 @default.
- W1587763824 cites W2103689548 @default.
- W1587763824 cites W2107908226 @default.
- W1587763824 cites W2134311390 @default.
- W1587763824 cites W2136145860 @default.
- W1587763824 cites W2145246787 @default.
- W1587763824 cites W2157603347 @default.
- W1587763824 cites W2163995157 @default.
- W1587763824 cites W2224139360 @default.
- W1587763824 cites W3111148255 @default.
- W1587763824 cites W4211195301 @default.
- W1587763824 doi "https://doi.org/10.1016/s0021-9258(20)80634-6" @default.
- W1587763824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8104945" @default.
- W1587763824 hasPublicationYear "1993" @default.
- W1587763824 type Work @default.
- W1587763824 sameAs 1587763824 @default.
- W1587763824 citedByCount "28" @default.
- W1587763824 countsByYear W15877638242012 @default.
- W1587763824 countsByYear W15877638242013 @default.
- W1587763824 crossrefType "journal-article" @default.
- W1587763824 hasAuthorship W1587763824A5010489983 @default.
- W1587763824 hasAuthorship W1587763824A5076950957 @default.
- W1587763824 hasAuthorship W1587763824A5086391681 @default.
- W1587763824 hasBestOaLocation W15877638241 @default.
- W1587763824 hasConcept C185592680 @default.
- W1587763824 hasConcept C189165786 @default.
- W1587763824 hasConcept C55493867 @default.
- W1587763824 hasConcept C86492073 @default.
- W1587763824 hasConcept C86803240 @default.
- W1587763824 hasConcept C95444343 @default.
- W1587763824 hasConceptScore W1587763824C185592680 @default.
- W1587763824 hasConceptScore W1587763824C189165786 @default.
- W1587763824 hasConceptScore W1587763824C55493867 @default.
- W1587763824 hasConceptScore W1587763824C86492073 @default.
- W1587763824 hasConceptScore W1587763824C86803240 @default.
- W1587763824 hasConceptScore W1587763824C95444343 @default.
- W1587763824 hasIssue "29" @default.
- W1587763824 hasLocation W15877638241 @default.
- W1587763824 hasOpenAccess W1587763824 @default.
- W1587763824 hasPrimaryLocation W15877638241 @default.
- W1587763824 hasRelatedWork W1531601525 @default.
- W1587763824 hasRelatedWork W2319480705 @default.
- W1587763824 hasRelatedWork W2384464875 @default.
- W1587763824 hasRelatedWork W2398689458 @default.
- W1587763824 hasRelatedWork W2606230654 @default.
- W1587763824 hasRelatedWork W2607424097 @default.
- W1587763824 hasRelatedWork W2748952813 @default.
- W1587763824 hasRelatedWork W2899084033 @default.
- W1587763824 hasRelatedWork W2948807893 @default.
- W1587763824 hasRelatedWork W2778153218 @default.
- W1587763824 hasVolume "268" @default.
- W1587763824 isParatext "false" @default.
- W1587763824 isRetracted "false" @default.
- W1587763824 magId "1587763824" @default.