Matches in SemOpenAlex for { <https://semopenalex.org/work/W1587785613> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1587785613 endingPage "372" @default.
- W1587785613 startingPage "358" @default.
- W1587785613 abstract "The stability of biological models is an important test for establishing their soundness and accuracy. Stability in biological systems represents the ability of a robust system to always return to homeostasis. In recent work, modular approaches for proving stability have been found to be swift and scalable. If stability is however not proved, the currently available techniques apply an exhaustive search through the unstable state space to find loops. This search is frequently prohibitively computationally expensive, limiting its usefulness. Here we present a new modular approach eliminating the need for an exhaustive search for loops. Using models of biological systems we show that the technique finds loops significantly faster than brute force approaches. Furthermore, for a subset of stable systems which are resistant to modular proofs, we observe a speed up of up to 3 orders of magnitude as the exhaustive searches for loops which cause instability are avoided. With our new procedure we are able to prove instability and stability in a number of realistic biological models, including adaptation in bacterial chemotaxis, the lambda phage lysogeny/lysis switch, voltage gated channel opening and cAMP oscillations in the slime mold Dictyostelium discoideum. This new approach will support the development of new tools for biomedicine." @default.
- W1587785613 created "2016-06-24" @default.
- W1587785613 creator A5003921851 @default.
- W1587785613 creator A5027490511 @default.
- W1587785613 creator A5045161607 @default.
- W1587785613 creator A5056559851 @default.
- W1587785613 creator A5066495237 @default.
- W1587785613 creator A5086492427 @default.
- W1587785613 date "2014-01-01" @default.
- W1587785613 modified "2023-10-17" @default.
- W1587785613 title "Finding Instability in Biological Models" @default.
- W1587785613 cites W1480909796 @default.
- W1587785613 cites W1493523706 @default.
- W1587785613 cites W1534396082 @default.
- W1587785613 cites W1574030932 @default.
- W1587785613 cites W1575657391 @default.
- W1587785613 cites W1579045998 @default.
- W1587785613 cites W1788683850 @default.
- W1587785613 cites W1971224531 @default.
- W1587785613 cites W1986397618 @default.
- W1587785613 cites W1987145964 @default.
- W1587785613 cites W1994892791 @default.
- W1587785613 cites W1999908691 @default.
- W1587785613 cites W2034717053 @default.
- W1587785613 cites W2039053938 @default.
- W1587785613 cites W2041289840 @default.
- W1587785613 cites W2043100293 @default.
- W1587785613 cites W2064441783 @default.
- W1587785613 cites W2066322491 @default.
- W1587785613 cites W2133569473 @default.
- W1587785613 cites W2134978629 @default.
- W1587785613 cites W2161636210 @default.
- W1587785613 cites W4237394719 @default.
- W1587785613 doi "https://doi.org/10.1007/978-3-319-08867-9_24" @default.
- W1587785613 hasPublicationYear "2014" @default.
- W1587785613 type Work @default.
- W1587785613 sameAs 1587785613 @default.
- W1587785613 citedByCount "7" @default.
- W1587785613 countsByYear W15877856132014 @default.
- W1587785613 countsByYear W15877856132015 @default.
- W1587785613 countsByYear W15877856132017 @default.
- W1587785613 crossrefType "book-chapter" @default.
- W1587785613 hasAuthorship W1587785613A5003921851 @default.
- W1587785613 hasAuthorship W1587785613A5027490511 @default.
- W1587785613 hasAuthorship W1587785613A5045161607 @default.
- W1587785613 hasAuthorship W1587785613A5056559851 @default.
- W1587785613 hasAuthorship W1587785613A5066495237 @default.
- W1587785613 hasAuthorship W1587785613A5086492427 @default.
- W1587785613 hasBestOaLocation W15877856131 @default.
- W1587785613 hasConcept C101468663 @default.
- W1587785613 hasConcept C108710211 @default.
- W1587785613 hasConcept C111919701 @default.
- W1587785613 hasConcept C112972136 @default.
- W1587785613 hasConcept C119857082 @default.
- W1587785613 hasConcept C121332964 @default.
- W1587785613 hasConcept C199360897 @default.
- W1587785613 hasConcept C207821765 @default.
- W1587785613 hasConcept C2524010 @default.
- W1587785613 hasConcept C33923547 @default.
- W1587785613 hasConcept C39920170 @default.
- W1587785613 hasConcept C41008148 @default.
- W1587785613 hasConcept C48044578 @default.
- W1587785613 hasConcept C57879066 @default.
- W1587785613 hasConcept C77088390 @default.
- W1587785613 hasConceptScore W1587785613C101468663 @default.
- W1587785613 hasConceptScore W1587785613C108710211 @default.
- W1587785613 hasConceptScore W1587785613C111919701 @default.
- W1587785613 hasConceptScore W1587785613C112972136 @default.
- W1587785613 hasConceptScore W1587785613C119857082 @default.
- W1587785613 hasConceptScore W1587785613C121332964 @default.
- W1587785613 hasConceptScore W1587785613C199360897 @default.
- W1587785613 hasConceptScore W1587785613C207821765 @default.
- W1587785613 hasConceptScore W1587785613C2524010 @default.
- W1587785613 hasConceptScore W1587785613C33923547 @default.
- W1587785613 hasConceptScore W1587785613C39920170 @default.
- W1587785613 hasConceptScore W1587785613C41008148 @default.
- W1587785613 hasConceptScore W1587785613C48044578 @default.
- W1587785613 hasConceptScore W1587785613C57879066 @default.
- W1587785613 hasConceptScore W1587785613C77088390 @default.
- W1587785613 hasLocation W15877856131 @default.
- W1587785613 hasLocation W15877856132 @default.
- W1587785613 hasOpenAccess W1587785613 @default.
- W1587785613 hasPrimaryLocation W15877856131 @default.
- W1587785613 hasRelatedWork W2008256913 @default.
- W1587785613 hasRelatedWork W2099785256 @default.
- W1587785613 hasRelatedWork W2115198108 @default.
- W1587785613 hasRelatedWork W2163019390 @default.
- W1587785613 hasRelatedWork W2293412579 @default.
- W1587785613 hasRelatedWork W2604424424 @default.
- W1587785613 hasRelatedWork W2950202488 @default.
- W1587785613 hasRelatedWork W3037147088 @default.
- W1587785613 hasRelatedWork W3204711402 @default.
- W1587785613 hasRelatedWork W4310831925 @default.
- W1587785613 isParatext "false" @default.
- W1587785613 isRetracted "false" @default.
- W1587785613 magId "1587785613" @default.
- W1587785613 workType "book-chapter" @default.