Matches in SemOpenAlex for { <https://semopenalex.org/work/W1587798319> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1587798319 endingPage "260" @default.
- W1587798319 startingPage "244" @default.
- W1587798319 abstract "Outer hair cells (OHCs) of the mammalian cochlea are equipped with a specific form of cellular motility that is driven by changes of the membrane potential. This electromotility is a membrane-based process generated by the membrane protein prestin (SLC26A5). Current models suggest that prestin undergoes a force-generating conformational transition upon changes of the membrane potential. The voltage dependence of prestin needs to be mediated by a charged particle within the protein, a 'voltage sensor', that can move through the membrane electrical field to trigger these conformational rearrangements. Indeed, voltage sensor translocation can be measured as electrical charge transfer. Here, we review and extend data indicating that charge movement by prestin and consequently electromotility depend on the presence of small monovalent anions such as chloride and bicarbonate at the cytoplasmic side of the membrane. The voltage dependence of prestin varies with concentration and species of the anion present, consistent with a partial translocation of the anion through the membrane. Thus anions may act as extrinsic voltage sensors. These conclusions suggest that charge movement and subsequent conformational rearrangements may relate to anion transport by other SLC26 members. Insights into molecular properties of prestin may provide clues to common mechanisms of anion transport by SLC26 proteins." @default.
- W1587798319 created "2016-06-24" @default.
- W1587798319 creator A5025902783 @default.
- W1587798319 creator A5048862873 @default.
- W1587798319 creator A5083310937 @default.
- W1587798319 date "2006-06-30" @default.
- W1587798319 modified "2023-10-01" @default.
- W1587798319 title "Interaction of Prestin (SLC26A5) with Monovalent Intracellular Anions" @default.
- W1587798319 doi "https://doi.org/10.1002/0470029579.ch16" @default.
- W1587798319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17120772" @default.
- W1587798319 hasPublicationYear "2006" @default.
- W1587798319 type Work @default.
- W1587798319 sameAs 1587798319 @default.
- W1587798319 citedByCount "13" @default.
- W1587798319 countsByYear W15877983192014 @default.
- W1587798319 countsByYear W15877983192016 @default.
- W1587798319 countsByYear W15877983192017 @default.
- W1587798319 countsByYear W15877983192018 @default.
- W1587798319 countsByYear W15877983192020 @default.
- W1587798319 countsByYear W15877983192021 @default.
- W1587798319 countsByYear W15877983192022 @default.
- W1587798319 crossrefType "other" @default.
- W1587798319 hasAuthorship W1587798319A5025902783 @default.
- W1587798319 hasAuthorship W1587798319A5048862873 @default.
- W1587798319 hasAuthorship W1587798319A5083310937 @default.
- W1587798319 hasConcept C12554922 @default.
- W1587798319 hasConcept C144647389 @default.
- W1587798319 hasConcept C181911157 @default.
- W1587798319 hasConcept C185592680 @default.
- W1587798319 hasConcept C20418707 @default.
- W1587798319 hasConcept C2780898785 @default.
- W1587798319 hasConcept C41625074 @default.
- W1587798319 hasConcept C55493867 @default.
- W1587798319 hasConcept C57181701 @default.
- W1587798319 hasConcept C57581600 @default.
- W1587798319 hasConcept C86803240 @default.
- W1587798319 hasConcept C93126451 @default.
- W1587798319 hasConcept C95444343 @default.
- W1587798319 hasConceptScore W1587798319C12554922 @default.
- W1587798319 hasConceptScore W1587798319C144647389 @default.
- W1587798319 hasConceptScore W1587798319C181911157 @default.
- W1587798319 hasConceptScore W1587798319C185592680 @default.
- W1587798319 hasConceptScore W1587798319C20418707 @default.
- W1587798319 hasConceptScore W1587798319C2780898785 @default.
- W1587798319 hasConceptScore W1587798319C41625074 @default.
- W1587798319 hasConceptScore W1587798319C55493867 @default.
- W1587798319 hasConceptScore W1587798319C57181701 @default.
- W1587798319 hasConceptScore W1587798319C57581600 @default.
- W1587798319 hasConceptScore W1587798319C86803240 @default.
- W1587798319 hasConceptScore W1587798319C93126451 @default.
- W1587798319 hasConceptScore W1587798319C95444343 @default.
- W1587798319 hasLocation W15877983191 @default.
- W1587798319 hasLocation W15877983192 @default.
- W1587798319 hasOpenAccess W1587798319 @default.
- W1587798319 hasPrimaryLocation W15877983191 @default.
- W1587798319 hasRelatedWork W1532866888 @default.
- W1587798319 hasRelatedWork W1587798319 @default.
- W1587798319 hasRelatedWork W1608300107 @default.
- W1587798319 hasRelatedWork W1969099004 @default.
- W1587798319 hasRelatedWork W1983087390 @default.
- W1587798319 hasRelatedWork W2000409942 @default.
- W1587798319 hasRelatedWork W2067857671 @default.
- W1587798319 hasRelatedWork W2070044371 @default.
- W1587798319 hasRelatedWork W2079233479 @default.
- W1587798319 hasRelatedWork W3188833157 @default.
- W1587798319 isParatext "false" @default.
- W1587798319 isRetracted "false" @default.
- W1587798319 magId "1587798319" @default.
- W1587798319 workType "other" @default.