FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1587801474> ?p ?o ?g. }

• W1587801474 endingPage "159" @default.
• W1587801474 startingPage "151" @default.
• W1587801474 abstract "The triple-helical cyanogen-bromide-derived fragment CB3[IV] of collagen IV, located 100 nm from the N-terminus of the molecule, contains the binding sites for the integrins alpha 1 beta 1 and alpha 2 beta 1. To investigate the interaction of these integrins and collagen IV, we performed solid-phase and inhibition assays using as receptor isolated alpha 1 beta 1 and alpha 2 beta 1. The ligands used were the binding-site-bearing trimeric peptide CB3[IV] and its shorter tryptic fragments F1-F4. Using titration curves, in which the binding of soluble receptors to coated ligands and the binding of soluble ligands to coated receptors were analyzed, the binding sites for alpha 1 beta 1 and alpha 2 beta 1 were in different but adjacent areas of CB3[IV]. Triple-helical conformation and distinct primary structures were required for the interaction. Dissociation constants (Kd), for the affinity of integrins for collagen IV, were determined in the 1-nM range in the presence of Mn2+ and Mg2+. In the absence of Mn2+, the Kd values indicated a 30-60-fold decrease in the affinities, which for alpha 2 beta 1 was further reduced by adding Ca2+. In the presence of Ca2+ and Mg2+ the affinity of collagen IV for alpha 1 beta 1 was four-times higher than for alpha 2 beta 1." @default.
• W1587801474 created "2016-06-24" @default.
• W1587801474 creator A5019791170 @default.
• W1587801474 creator A5021076969 @default.
• W1587801474 creator A5034461662 @default.
• W1587801474 creator A5058659429 @default.
• W1587801474 date "1993-07-01" @default.
• W1587801474 modified "2023-09-29" @default.
• W1587801474 title "Interaction of type IV collagen with the isolated integrins alpha1beta1 and alpha2beta1" @default.
• W1587801474 cites W1483065892 @default.
• W1587801474 cites W1498798237 @default.
• W1587801474 cites W1498888463 @default.
• W1587801474 cites W1501642560 @default.
• W1587801474 cites W1502280728 @default.
• W1587801474 cites W1515444240 @default.
• W1587801474 cites W1525292585 @default.
• W1587801474 cites W1559390072 @default.
• W1587801474 cites W1568828918 @default.
• W1587801474 cites W1604526865 @default.
• W1587801474 cites W1605746073 @default.
• W1587801474 cites W1606308790 @default.
• W1587801474 cites W1764824114 @default.
• W1587801474 cites W1969467769 @default.
• W1587801474 cites W1973064020 @default.
• W1587801474 cites W1973834594 @default.
• W1587801474 cites W197431773 @default.
• W1587801474 cites W1981689192 @default.
• W1587801474 cites W1985091171 @default.
• W1587801474 cites W1987718692 @default.
• W1587801474 cites W1988645163 @default.
• W1587801474 cites W1993402154 @default.
• W1587801474 cites W1998247442 @default.
• W1587801474 cites W1999794993 @default.
• W1587801474 cites W2002712489 @default.
• W1587801474 cites W2005007281 @default.
• W1587801474 cites W2012043046 @default.
• W1587801474 cites W2013271152 @default.
• W1587801474 cites W2013381560 @default.
• W1587801474 cites W2021802757 @default.
• W1587801474 cites W2026857452 @default.
• W1587801474 cites W2028641623 @default.
• W1587801474 cites W2034244905 @default.
• W1587801474 cites W2049440576 @default.
• W1587801474 cites W2056031607 @default.
• W1587801474 cites W2057892928 @default.
• W1587801474 cites W2065918211 @default.
• W1587801474 cites W2082402523 @default.
• W1587801474 cites W2121779993 @default.
• W1587801474 cites W2123692893 @default.
• W1587801474 cites W2135057126 @default.
• W1587801474 cites W2149429580 @default.
• W1587801474 cites W2333443761 @default.
• W1587801474 cites W2408084798 @default.
• W1587801474 cites W2414459132 @default.
• W1587801474 doi "https://doi.org/10.1111/j.1432-1033.1993.tb18017.x" @default.
• W1587801474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8344274" @default.
• W1587801474 hasPublicationYear "1993" @default.
• W1587801474 type Work @default.
• W1587801474 sameAs 1587801474 @default.
• W1587801474 citedByCount "207" @default.
• W1587801474 countsByYear W15878014742012 @default.
• W1587801474 countsByYear W15878014742013 @default.
• W1587801474 countsByYear W15878014742014 @default.
• W1587801474 countsByYear W15878014742015 @default.
• W1587801474 countsByYear W15878014742016 @default.
• W1587801474 countsByYear W15878014742017 @default.
• W1587801474 countsByYear W15878014742018 @default.
• W1587801474 countsByYear W15878014742019 @default.
• W1587801474 countsByYear W15878014742020 @default.
• W1587801474 countsByYear W15878014742021 @default.
• W1587801474 countsByYear W15878014742022 @default.
• W1587801474 countsByYear W15878014742023 @default.
• W1587801474 crossrefType "journal-article" @default.
• W1587801474 hasAuthorship W1587801474A5019791170 @default.
• W1587801474 hasAuthorship W1587801474A5021076969 @default.
• W1587801474 hasAuthorship W1587801474A5034461662 @default.
• W1587801474 hasAuthorship W1587801474A5058659429 @default.
• W1587801474 hasBestOaLocation W15878014741 @default.
• W1587801474 hasConcept C104317684 @default.
• W1587801474 hasConcept C107824862 @default.
• W1587801474 hasConcept C159110408 @default.
• W1587801474 hasConcept C167625842 @default.
• W1587801474 hasConcept C170493617 @default.
• W1587801474 hasConcept C185592680 @default.
• W1587801474 hasConcept C195687474 @default.
• W1587801474 hasConcept C199360897 @default.
• W1587801474 hasConcept C2775944032 @default.
• W1587801474 hasConcept C2776174256 @default.
• W1587801474 hasConcept C2777093645 @default.
• W1587801474 hasConcept C2779281246 @default.
• W1587801474 hasConcept C41008148 @default.
• W1587801474 hasConcept C49453240 @default.
• W1587801474 hasConcept C55493867 @default.
• W1587801474 hasConcept C64943373 @default.
• W1587801474 hasConcept C71240020 @default.
• W1587801474 hasConcept C71924100 @default.
• W1587801474 hasConcept C74998103 @default.
• W1587801474 hasConcept C8010536 @default.

• next