FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1587810042> ?p ?o ?g. }

• W1587810042 endingPage "272" @default.
• W1587810042 startingPage "266" @default.
• W1587810042 abstract "Plasmodium falciparum sirtuin, PfSir2, contains histone deacetylase (HDAC) activity that may be central to the regulation of virulence gene expression in the parasites. Although a few reports have been published recently regarding in vitro and in vivo function of PfSir2, expression of the endogenous protein (c. 30 kDa) has not been shown yet. Here we report the presence of PfSir2 in the parasite at the protein level by specific antibodies. HDAC activity of PfSir2 can be inhibited by nicotinamide, a product of sirtuin reaction. Surprisingly, we find that nicotinamide also delays parasite growth significantly in culture. These findings further our knowledge on PfSir2 and raise the possibility of using an inexpensive agent like nicotinamide as an antimalarial in combination with other antiparasitic drugs." @default.
• W1587810042 created "2016-06-24" @default.
• W1587810042 creator A5002288405 @default.
• W1587810042 creator A5019435227 @default.
• W1587810042 creator A5035827860 @default.
• W1587810042 creator A5050824308 @default.
• W1587810042 creator A5056040667 @default.
• W1587810042 creator A5060237743 @default.
• W1587810042 creator A5079097546 @default.
• W1587810042 date "2008-04-04" @default.
• W1587810042 modified "2023-09-23" @default.
• W1587810042 title "Nicotinamide inhibits Plasmodium falciparum Sir2 activity in vitro and parasite growth" @default.
• W1587810042 cites W1969503178 @default.
• W1587810042 cites W1977082621 @default.
• W1587810042 cites W1983970357 @default.
• W1587810042 cites W1997028850 @default.
• W1587810042 cites W2011326960 @default.
• W1587810042 cites W2019433244 @default.
• W1587810042 cites W2020251171 @default.
• W1587810042 cites W2038522569 @default.
• W1587810042 cites W2046232891 @default.
• W1587810042 cites W2152921443 @default.
• W1587810042 cites W2167990179 @default.
• W1587810042 doi "https://doi.org/10.1111/j.1574-6968.2008.01135.x" @default.
• W1587810042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18397290" @default.
• W1587810042 hasPublicationYear "2008" @default.
• W1587810042 type Work @default.
• W1587810042 sameAs 1587810042 @default.
• W1587810042 citedByCount "55" @default.
• W1587810042 countsByYear W15878100422012 @default.
• W1587810042 countsByYear W15878100422013 @default.
• W1587810042 countsByYear W15878100422014 @default.
• W1587810042 countsByYear W15878100422015 @default.
• W1587810042 countsByYear W15878100422016 @default.
• W1587810042 countsByYear W15878100422017 @default.
• W1587810042 countsByYear W15878100422018 @default.
• W1587810042 countsByYear W15878100422019 @default.
• W1587810042 countsByYear W15878100422020 @default.
• W1587810042 countsByYear W15878100422021 @default.
• W1587810042 countsByYear W15878100422022 @default.
• W1587810042 countsByYear W15878100422023 @default.
• W1587810042 crossrefType "journal-article" @default.
• W1587810042 hasAuthorship W1587810042A5002288405 @default.
• W1587810042 hasAuthorship W1587810042A5019435227 @default.
• W1587810042 hasAuthorship W1587810042A5035827860 @default.
• W1587810042 hasAuthorship W1587810042A5050824308 @default.
• W1587810042 hasAuthorship W1587810042A5056040667 @default.
• W1587810042 hasAuthorship W1587810042A5060237743 @default.
• W1587810042 hasAuthorship W1587810042A5079097546 @default.
• W1587810042 hasBestOaLocation W15878100421 @default.
• W1587810042 hasConcept C104317684 @default.
• W1587810042 hasConcept C127561419 @default.
• W1587810042 hasConcept C181199279 @default.
• W1587810042 hasConcept C199848840 @default.
• W1587810042 hasConcept C202751555 @default.
• W1587810042 hasConcept C203014093 @default.
• W1587810042 hasConcept C2776536020 @default.
• W1587810042 hasConcept C2778048844 @default.
• W1587810042 hasConcept C2778305200 @default.
• W1587810042 hasConcept C2778371730 @default.
• W1587810042 hasConcept C2779728014 @default.
• W1587810042 hasConcept C2780561631 @default.
• W1587810042 hasConcept C55493867 @default.
• W1587810042 hasConcept C64927066 @default.
• W1587810042 hasConcept C75520062 @default.
• W1587810042 hasConcept C86803240 @default.
• W1587810042 hasConceptScore W1587810042C104317684 @default.
• W1587810042 hasConceptScore W1587810042C127561419 @default.
• W1587810042 hasConceptScore W1587810042C181199279 @default.
• W1587810042 hasConceptScore W1587810042C199848840 @default.
• W1587810042 hasConceptScore W1587810042C202751555 @default.
• W1587810042 hasConceptScore W1587810042C203014093 @default.
• W1587810042 hasConceptScore W1587810042C2776536020 @default.
• W1587810042 hasConceptScore W1587810042C2778048844 @default.
• W1587810042 hasConceptScore W1587810042C2778305200 @default.
• W1587810042 hasConceptScore W1587810042C2778371730 @default.
• W1587810042 hasConceptScore W1587810042C2779728014 @default.
• W1587810042 hasConceptScore W1587810042C2780561631 @default.
• W1587810042 hasConceptScore W1587810042C55493867 @default.
• W1587810042 hasConceptScore W1587810042C64927066 @default.
• W1587810042 hasConceptScore W1587810042C75520062 @default.
• W1587810042 hasConceptScore W1587810042C86803240 @default.
• W1587810042 hasIssue "2" @default.
• W1587810042 hasLocation W15878100421 @default.
• W1587810042 hasLocation W15878100422 @default.
• W1587810042 hasOpenAccess W1587810042 @default.
• W1587810042 hasPrimaryLocation W15878100421 @default.
• W1587810042 hasRelatedWork W1587810042 @default.
• W1587810042 hasRelatedWork W1989666486 @default.
• W1587810042 hasRelatedWork W2033393247 @default.
• W1587810042 hasRelatedWork W2072808244 @default.
• W1587810042 hasRelatedWork W2078190587 @default.
• W1587810042 hasRelatedWork W2277544136 @default.
• W1587810042 hasRelatedWork W2294046536 @default.
• W1587810042 hasRelatedWork W2344957911 @default.
• W1587810042 hasRelatedWork W2912920575 @default.
• W1587810042 hasRelatedWork W2952774436 @default.
• W1587810042 hasVolume "282" @default.

• next