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- W1588057063 abstract "The use of plant (cell) suspension cultures in phototrophic mode on an industrially relevant scale is limited to two systems worldwide. These are the moss-based BryoTechnology™ and the duckweed-based SYNLEX™ production systems being developed by greenovation biotech GmbH and Synthon, respectively. Both production platforms make use of intact plants, rather than isolated cells, which are grown in simple salt media to manufacture recombinant, high value pharmaceutical proteins. They exploit unique features of plants like homogenous N-glycosylation, absolute genetic stability, and pathogen safety to create biopharmaceuticals of outstanding quality. On the equipment side, both processes build on single use, disposable solutions bringing about high flexibility and regulatory safety. Despite sharing all of the above-mentioned aspects, these two systems differ remarkably in several details. Physcomitrella patens, the moss behind BryoTechnology™, is unique in its potential for genetic engineering. Resembling yeast systems in that aspect, it allows for rapid generation of product-tailored production platforms. The SYNLEX™-system on the other hand, with Lemna minor as producing organism has a very basic process setup with few controls and good scale-up potential. This chapter discusses strengths and weaknesses of both systems side-by-side, describes their current technological development status, and gives a short future outlook." @default.
- W1588057063 created "2016-06-24" @default.
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- W1588057063 date "2014-06-18" @default.
- W1588057063 modified "2023-10-18" @default.
- W1588057063 title "Suspension Culture of Plant Cells Under Phototrophic Conditions" @default.
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- W1588057063 doi "https://doi.org/10.1002/9783527683321.ch08" @default.
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